Gliclazide

Category:Active Pharmaceutical Ingredients > Antibiotics > Other Antibiotics
Product Name:Gliclazide
Company:JIANGSU GTIG HUATAI CO., LTD.

Basic Info
  • Factory Location: Zhangjiagang, Jiangsu, China

    Main Sales Markets: North America,Central/South America,Western Europe,Asia,Africa

  • Monthly Production Capacity: 100MT

    Packaging Information: 25kg drum

  • Sample Provided: no

    Payment Terms: T/T

    Gliclazide is an oral antihyperglycemic agent used for the treatment of diabetes mellitus type II. It belongs to the sulfonylurea class of insulin secretagogues, which stimulates β cells of the pancreas to release insulin. Gliclazide binds to the β cell sulfonyl urea receptor (SUR1), further blocking the ATP sensitive potassium channels. Therefore, the potassium efflux substantially decreases, causing depolarization of the β cells. Then the voltage-dependent calcium channels in the β cell are open, resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules. Recent studies have also shown that gliclazide can effectiveimprove anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes and protect pancreatic beta-cells from damage by hydrogen peroxide.

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