ALPROSTADIL 745-65-3

Category:Active Pharmaceutical Ingredients > Prostaglandins
Product Name:ALPROSTADIL 745-65-3
CAS No.:745-65-3
Standard:USP, BP, EP, JP, In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co., Ltd.

Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Xiamen, Fujian

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East

  • Sample Provided: yes

    Payment Terms: L/L

    Product Information

     

    Product name

    Alprostadil

    Molecular Formula

    C20H34O5

    Molecular Weight

    354.48

    CAS No.

    745-65-3

    Quality Standard

    95% up, USP26

    Appearance

    White powder

     

    COA of Alprostadil

     

    Items

    Specifications

    Results

    Appearance

    White to off-white powder

    Complies

    Identification

    HPLC retention time of sample complies with that of known sample

    Complies

    Water

    ≤0.5%

    0.03%

    Residual solvents

    ≤0.5%

    0.02%

    Residual on ignition

    ≤0.5%

    0.20%

    Related substances

    PGAI:≤0.5%

    Undetected

    PGBI:≤0.5%

    Undetected

    13,14-Dihydro-PGEI: ≤0.5%

    Undetected

    Other impurities: ≤ 0.5%

    Undetected

    Assay

    95.0%~105.0%

    99.00%

     

    Usage

     

    Function of Alprostadil
    Alprostadil, alias PGE1PGE1 is a biologically active substance widely present in the body, the mechanism of treating diabetic neuropathy:

    1. Improve hemodynamics, increase the CAMP content in vascular smooth muscle cells, exert its vasodilator effect and reduce peripheral resistance;

    2. To improve blood rheology, PGE can inhibit platelet aggregation, reduce platelet high response and thromboxane A (TXA) level, inhibit platelet activation, promote the reversal of activated platelets around thrombus, and improve the deformability of red blood cells;

    3. PGE can activate lipoproteinase and promote triglyceride hydrolysis, reduce blood lipids and blood viscosity;

    4. PGE can stimulate vascular endothelial cells to produce tissue-type fibrinolytic substance (t-PA), which has a certain direct thrombolytic effect.

    5. By inhibiting free Caz of vascular smooth muscle cells and inhibiting the release of norepinephrine from vascular sympathetic nerve endings, the vascular smooth muscle is relaxed and the microcirculation is improved.

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