98% up by HPLC Tacrolimus FK-506 104987-11-3

Function of Tacrolimus

Tacrolimus (FK506), a macrolide, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase (calcineurin phosphatase), thereby inhibiting T lymphocyte signal transduction and IL-2 transcription, with strong Immunosuppressive properties. In recent years, as a first-line drug for liver and kidney transplantation, it has been marketed in 14 countries including Japan and the United States. Clinical experiments show that it has a good effect in transplantation of heart, lung, intestine, bone marrow, etc. At the same time, FK506 also plays an active role in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune diseases.