
Standard Member
(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propano-3aH-cyclopentacycloocten-8-yl[[2-(diethylamino)ethyl]sulphanyl]acetate hydrogen (E)-butenedioate.
All pass 24mesh sieve, the quantity through 80 mesh sieve should be not more than 10.0%.
Preserve in tight, light-resistant containers, and store at room temperature.
Tiamulin fumarate is a semi-synthetic diterpene antibiotic. The mode of action is by inhibition of ribosomal protein synthesis in sensitive bacteria. It is a bacteriostatic antibiotic and the following organisms show sensitivity in vitro:
Brachyspira: Brachyspira hyodysenteriae, Brachyspira pilosicoli
Mycoplasmas: Mycoplasma hyopneumoniae, M.hyorhinis, M. hyosynoviae, Ureaplasma spp.
Gram-positive: Staphylococcus spp., Streptococcus spp., Corynebacterium pyogenes.
Gram-negative: Pasteurella spp., Klebsiella pneumoniae, Actinobacillus (Haemophilus) spp., Fusobacterium necrophorum, Bacteroides spp., Campylobacter coli, Lawsonia intracellularis.
Following oral administration, tiamulin fumarate is rapidly absorbed and peak serum concentrations are achieved 2 - 4 hours after administration and concentrates in some tissues e.g. lung. Following absorption, it is rapidly metabolized and excreted.
For the treatment, prevention and control of swine dysentery caused by Brachyspira hyodysenteriae and complicated by Fusobacterium and Bacteroides spp. As an aid in the control of the enzootic pneumonia complex in pigs.
Mix with feed:
For pig: Every 1000kg feed, 40~100g Tiamulin fumarate, for 5~10 days consecutively.
Animals should not receive products containing monensin, narasin or salinomycin, during or for at least seven days before or after treatment with tiamulin.