Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a peptide composed of 37 amino acids. It belongs to one of the neuropeptides of the calcitonin family and exerts biological effects through (CRLR). Calcitonin gene-related peptide plays a key role in the pathophysiology of migraine and is related to the activation of the trigeminal neurovascular system. Calcitonin Gene Related Peptide (CGRP) (83-119), rat may be related to primary headache in these Functions in the relevant area.