Endotoxin is not only the main pathogenic factor of Gram-negative bacterial infection, but also an important factor that is still endangering the health of animals and humans. Therefore, the research on anti-endotoxin suppression measures is particularly important. The 10-amino acid peptide Endotoxin Inhibitor has a strong role in blocking the physiological activity of bacteria, thereby producing antibacterial effect. The Endotoxin Inhibitor sequence contains disulfide bonds and a large amount of lysine, which is more likely to exert physiological activity under acidic conditions.