Category:
Peptides
CAS NO:
851199-59-2
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Basic Info
Grade
Research grade
Product Keywords
Linaclotide
Is Manufacturer
No
Packaging Specification
1g, 5g, 10g, 20g, 50g,100g
Minimum Order Quantity
1g
Payment Method
bank transit
Delivery Cycle
In stock or 2-3weeks
Samples Provided
YES
Sample Policy
1-10mg for free
Product Description
Linaclotide and its active metabolite bind and agonize guanylate cyclase-C on the luminal surface of intestinal epithelium. Intracellular and extracellular cyclic guanosine monophosphate (cGMP) concentrations are subsequently increased resulting in chloride and bicarbonate secretion into the intestinal lumen. Intestinal fluid increases and GI transit is accelerated. Increased extracellular cGMP may decrease visceral pain by reducing pain-sensing nerve activity.
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