Nesiritide, as a total agonist peptide, can increase the level of cyclic guanylic acid in target cells in the biological body, thereby promoting smooth muscle cell relaxation, dilating veins and arteries, and exerting its natriuretic, diuretic, vasodilator and smooth muscle relaxation. effect. Since Nesiritide has a β-sheet structure, a suitable condensing agent is selected for sequence in peptide synthesis.