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Products

Active Pharmaceutical Ingredients

Relugolix

Category:

Active Pharmaceutical Ingredients

CAS NO:

737789-87-6

Standard:

ChP,USP,BP,EP,JP,In-house Standards,IP,Ph. Int,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Asia,Middle East,Africa

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Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd.

Years

Standard Member

Show Room

Favorites

Basic Info

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Payment Method

L/C

Samples Provided

YES

Product Description

Relugolix Biological Activity

Description:Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013.target: GnRH [1]IC50: 0.33 nM [1]In vivo: In female knock-in mice, twice-daily oral administration of TAK-385 (100mg/kg) induces constant diestrous phases within the first week, decreases the uterus weight to ovariectomized levels and downregulated GnRH receptor mRNA in the pituitary after 4 weeks.

Molecular Formula:C29H27F2N7O5S

Molecular Weight:623.63

PSA:169.36000

LogP:3.96660