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Suzhou Aitesen Pharmaceutical Equipment Co., Ltd.
2
Years
Standard Member
Basic Info
Is Manufacturer
YES
Payment Method
other
Product Description
TANGENTIAL FLOW FILTRATION
BRIEF INTRODUCTION
AITESEN LDS series Tangential Flow Filtration is mainly applied in the research of tangential flow ultrafiltration technology for micro & nano drugs and biological products, providing excellent technical services and solutions.
The equipment can be used for process research experiments on small-scale samples, as well as for large-scale process validation experiments. The equipment is equipped with a touch screen operating system and software programs for automatic data recording, supporting data tracing and export. The process is reliable and suitable for programmatic amplification. The components comply with pharmaceutical industry standards, they are safe and reliable.
TFF:
Tangential Flow Filtration (TFF) is currently a widely used membrane separation technology. The sample is driven by pressure, and the content is separated by membrane filtration according to different molecular sizes, achieving the goals of removing heat, replacing the solution environment, purification ,and concentration.
PRINCIPLE：
The implementation process of TFF is fundamentally different from dead end filtration. As the filtrate passes through the membrane components, the sample solution continuously passes through the membrane surface in a vertical direction.
MEMBRANE PARTS：
用于切向流过滤的膜组件通常是膜组件或中空纤维柱，两者都有多种型号，以满足不同的使用需求。膜材料的种类和孔径、溶液循环流速、膜两侧压力、样品温度、膜两侧工艺、样品温度、工艺时间等参数对于切向流过滤非常重要。他们决定了最终的工艺效果，以及大规模生产的可行性和具体计划。实验室规模的切向流过滤设备致力于获得可行的工艺方案和可靠的工艺参数，确定适合大规模实验和生产的工艺参数，为设备或系统选型提供有效依据。
T FF流程图
应用领域
核酸药物和疫苗
mRNA-LNP、siRNA、聚合物纳米颗粒等
化疗脂质体
盐酸阿霉素脂质体
盐酸伊立替康脂质体
柔红霉素脂质体
复合脂质体等
解决方案系统位移
替代缓冲溶液
纳米药物溶液的外置水相置换
细胞产物分离纯化
发酵液细胞的收集和纯化
澄清过程
质粒、单克隆抗体、蛋白纯化
质粒、mRNA、siRNA等
LDS-L1 切向流过滤
技术参数S：
|
Model |
LDS-L1型 |
|
最小 S充足的 Volume |
≤30毫升 |
|
压力R ange |
-1-5巴 |
|
最大 F低 R吃 |
≥2200毫升/分钟 |
|
重量 Range |
0–4100克 |
|
一个ccuracy |
±0.5% |
|
可显示的 Data |
P f（进料压力）、P r（回流压力）、Pp（渗透压力）、TMP（跨膜压力）、△P（压降）等。 |
|
适用 M embrane Materials |
PES/纤维素膜包装，中空纤维 |
|
薄膜包装规格 |
5~1000 Kd;0.01~0.1m2 |
设备特点：
自动 Ultrafiltration S系统
它可以实现无人化的自动化TFF过程，并通过在集成PLC软件平台内对用户指定设置进行集成监控来执行复杂的TFF过程。
专业 Operating System
具有简单操作逻辑、实时跟踪、实时数据分析以及符合 FDA 21 CFR PART 11 数据审计跟踪的专用软件。
药物研发
设备设计基于药物研发生产的工艺要求和监管规范，可用于脂质体、脂质纳米颗粒等制剂的纯化、溶剂去除、浓缩等工艺的实施。
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