Biochemical assays for screening workshop

Access the latest cell based assays for screening technologies
3 day practical workshop

Drug Target Review and European ScreeningPort are pleased to present a unique practical workshop covering the development of biochemical assays for screening purposes.

Taking place over three days at the European ScreeningPort facility in Hamburg, the workshop will offer attendees the chance to participate in practical sessions using the latest technology available from six of the top screening equipment / reagent vendors in the pharmaceutical industry.

This is a must-attend event for anyone in the drug discovery industry to learn about screening technologies and discover what they can do for your company or laboratory.

Workshop topics include
• Choice of biochemical assay development projects: kinase, protease or histone deacetylase
• Kinetic characterization of enzymes
• Km determination for substrates
• IC50 determination for inhibitor, signal stability, choice of liquid handling and Z’
• Aspects of adaption of assays for screening of a small molecule library (known drugs)
• Data analysis and classifying compounds as Hits
• Interferers
• Validation of Hits selected from screening campaigns

Who should attend
• Scientists at all levels (undergraduates, postgraduates and laboratory based scientists within academic and industrial research organisations) who are engaged in early stage drug discovery and have an interest in the development, validation and utilisation of biochemical assays for screening against small molecule libraries.
• The course will include a series of lectures describing the screening compatible biochemical assays for use in drug discovery.
• The majority of the course will be laboratory based in which assays for targets that are currently actively being pursued for drug discovery purposes (kinases, histone deacetylases and proteases) will be developed, validated and screened against a small molecule library (known drugs). Selected Hit compounds will be evaluated in suitable Secondary assays.

Expected outcomes from the workshop
It is envisaged that upon completion of the course, attendees will have gained an insight into the key parameters to be considered when developing biochemical assays and performing small molecule screening, data analysis and validation of Hits in suitable Secondary assays.

Speaker Info: Dr Sheraz Gul
Sheraz Gul is Head of Biology at European ScreeningPort, Hamburg, Germany where he manages the assay development and screening of academic targets. Prior to this, he worked for GlaxoSmithKline for 7 years where he developed biochemical and cellular assays for High Throughput Screening as well as Hit characterization. In addition, he has worked in academia for 5 years on proteases and kinases. He is the co-authored of the Enzyme Assays: Essential Data Handbook.

EPR introduction:

European Pharmaceutical Review is the leading publication for information on technologies in drug discovery and manufacturing. Published bi-monthly, every issue offers a high level of technical and business contributions from the world’s leading pharmaceutical companies and academic institutions, coupled with a variety of exciting new features including interviews, updates and profiles.

European Pharmaceutical Review has been keeping the industry informed for more than 15 years and remains faithful to the key facets that serve its existing stakeholders so well; insights into current and emerging technologies, contributions from recognised figures in the life science community and quality presentation that makes every issue a reference tool for laboratories and offices across the world.

Price
EPR offer a special price of €1000 for all attendees through CPhI.

The biochemical assays for screening workshop offers a pricing structure that accommodates all levels of the pharmaceutical industry. As such we feel the workshop package offers great value for money, which includes:
• 3 days practical workshop using the latest technology available from the top screening equipments / reagent vendors in the pharmaceutical industry
• 3 nights’ accommodation in Hamburg, Germany
• Daily breakfast, lunch and refreshments
• One evening meal at the group dinner
• All supporting workshop materials