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Alzheimer’s

Alzheimer’s - Hypotheses & Drug Targets

Alzheimer’s Dementia Dementia Medications Blood-brain Barrier

The blood-brain barrier (BBB) is a physical barrier that keeps the extracellular fluid of the brain separate from the bloodstream.

July 31, 2023 by David Orchard-Webb

NIH study says repurposed cancer therapies beneficial for Alzheimer’s

NIH Alzheimer’s NIA

Scientists from the US National Institutes of Health (NIH) unit National Institute on Aging (NIA) have found that present and developing therapies for cancer could potentially...

November 12, 2021 by Pharmaceutical-Technology

Thinking impaired in 60% of COVID-19 survivors

COVID-19 Alzheimer’s de Erausquin SARS-CoV-2

In a sample of over 400 older adults in Argentina who had recovered from COVID-19, more than 60% displayed some degree of cognitive impairment, a researcher from The University of Texas Health Science Center at San Antonio reported July 29 at the ...

August 2, 2021 by worldpharmanews

Alzheimer’s treatment lowers tau by nearly 50 percent in Phase I trials

Alzheimer’s BIIB080 Ionis Biogen

Biogen and Ionis announced positive topline data on investigational Alzheimer’s treatment, indicating 50 percent tau protein reduction.

July 30, 2021 by europeanpharmaceuticalreview

Former FDA adviser calls for wider probe into Biogen Alzheimer’s drug approval

FDA Biogen Alzheimer’s Aduhelm

A federal probe of the US Food and Drug Administration’s approval of a controversial new Alzheimer’s disease drug should look into why that decision was made without clear evidence of patient benefit, a former adviser to the agency said 20th.

July 22, 2021 by expresspharma

Biogen gets US FDA accelerated approval for Aduhelm to treat Alzheimer’s

Biogen Alzheimer’s FDA Aduhelm

It is the first new treatment approved for Alzheimer's since 2003 and is the first therapy that targets the fundamental pathophysiology of the disease.

June 9, 2021 by expresspharma

FDA Approves Aducanumab To Treat Alzheimer’s Disease

FDA Aducanumab Alzheimer’s dementia

The U.S. Food and Drug Administration (FDA) has approved aducanumab, the first drug that slows Alzheimer's disease. Aducanumab is also the first novel therapy for Alzheimer’s disease approved since 2003.

June 9, 2021 by contractpharma

Alzheimer’s drug designed using Exscientia’s AI technology enters clinic

Alzheimer’s DSP-0038 Exscientia AI

An Alzheimer’s disease drug candidate designed using Exscientia’s artificial intelligence (AI) technology has entered Phase I clinical testing, the company announced May 13.

May 17, 2021 by pharmatimes

First AI designed Alzheimer’s drug to enter clinical trials

AI DSP-0038 Alzheimer’s Exscientia

The trial of DSP-0038, an Alzheimer’s disease psychosis drug designed using artificial intelligence, will assess its ability to improve the behavioural and psychological symptoms of dementia.

May 14, 2021 by europeanpharmaceuticalreview

Leukine® is beneficial to patients with mild-to-moderate Alzheimer’s, finds study

Leukine PTx Alzheimer’s GM-CSF

In a Phase II trial, Leukine® (sargramostim) significantly reduced biomarkers of neurodegeneration and improved cognitive function.

March 26, 2021 by europeanpharmaceuticalreview

Salbutamol significantly increases cerebral perfusion in proof-of-concept trial

CuraSen Alzheimer’s brain salbutamol

In the Phase I trial, the beta-2 adrenoceptor agonist salbutamol significantly increased cerebral perfusion, a key biomarker in neurodegenerative disease.

March 17, 2021 by europeanpharmaceuticalreview

Cassava Sciences Enters Drug Supply Agreement with Evonik

Cassava Evonik simufilam Alzheimer’s

Evonik will supply Cassava Sciences with large-scale, clinical-grade quantities of simufilam.

March 10, 2021 by contractpharma