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Industry Insights

Ionis

Biogen to obtain licence for Ionis’ investigational SMA therapy

Biogen Ionis BIIB115

Biogen will handle the expenses associated with the development, production and potential marketing of BIIB115.

January 6, 2022 by Pharmaceutical-Technology

AstraZeneca, Ionis close deal on antisense therapy development

AstraZeneca Ionis antisense therapy

under the deal, AstraZeneca will manage the development and marketing of the antisense therapy globally.

December 30, 2021 by pharmaceutical-business-review

AstraZeneca and Ionis partner to develop antisense therapy eplontersen

AstraZeneca Ionis eplontersen

AstraZeneca and Ionis Pharmaceuticals have signed an agreement to develop and market experimental therapy, eplontersen, previously called IONIS-TTR-LRX.

December 9, 2021 by Pharmaceutical-Technology

Alzheimer’s treatment lowers tau by nearly 50 percent in Phase I trials

Alzheimer’s BIIB080 Ionis Biogen

Biogen and Ionis announced positive topline data on investigational Alzheimer’s treatment, indicating 50 percent tau protein reduction.

July 30, 2021 by europeanpharmaceuticalreview

Ionis Appoints Clinical Development EVP

Eugene Schneider Ionis Clinical Development EVP

Eugene Schneider will oversee clinical development of novel antisense medicines across all of Ionis' therapeutic franchises.

January 11, 2021 by contractpharma

Ionis and Akcea announce that Pfizer initiated clinical study of vupanorsen

Ionis Akcea vupanorsen Pfizer

Ionis Pharmaceuticals and its wholly owned subsidiary Akcea Therapeutics, Inc., announced that Pfizer has initiated a Phase 2b study of vupanorsen (AKCEA-ANGPTL3-LRx) in statin-treated patients with elevated non-high-density lipoprotein cholesterol ...

November 6, 2020 by pharmaceutical-business-review

Ionis Begins ALS Clinical Trial

Ionis ALS ION541 TDP-43

Ionis Pharmaceuticals announced the first patients have been dosed with ION541 (also known as BIIB105), an investigational antisense medicine being developed as a potential therapy to treat most forms of amyotrophic lateral sclerosis (ALS) regardless ...

October 28, 2020 by americanpharmaceuticalreview

Ionis to Acquire Outstanding Shares of Akcea for $500M

Ionis Akcea acquisition

Ionis will benefit from Akcea's pipeline and commercial products, and further strengthens financial position to support future investments.

September 1, 2020 by contractpharma

Akcea, Ionis Announce Initiation of Trial for Amyloid Cardiomyopathy Treatment

Akcea Ionis ATTR cardiomyopathy AKCEA-TTR-LRx CARDIO-TTRansform

Akcea Therapeutics and Ionis Pharmaceuticals announced the initiation of the CARDIO-TTRansform Phase 3 cardiovascular outcomes study for AKCEA-TTR-LRx in patients with transthyretin-mediated amyloid cardiomyopathy (ATTR cardiomyopathy).

January 16, 2020 by americanpharmaceuticalreview

Empirico, Ionis collaborate to develop antisense oligonucleotide therapeutics

Empirico Ionis antisense oligonucleotide

Empirico has entered into a $660m deal with Ionis Pharmaceuticals to develop novel antisense oligonucleotide therapeutics. Under the three-year collaboration, Empirico will use its Precision Insights Platform to determine therapeutic targets for indicatio

January 14, 2020 by pharmaceutical-business-review

Aro Biotherapeutics signs licensing agreement worth up to $1.4bn

Aro Biotherapeutics Ionis ASO

Aro Biotherapeutics, a biotech firm engaged in the development of protein biologics called Centyrins, has signed a licencing deal that can potentially generate up to $1.4bn for the company.

January 13, 2020 by pharmaceutical-technology

Ionis Licenses Investigational Alzheimer's Therapy

Ionis Alzheimer IONIS-MAPTRx Biogen

Ionis Pharmaceuticals announced Biogen, a collaboration partner for neurological diseases, has licensed IONIS-MAPTRx, an antisense therapy designed to selectively reduce production ...

December 23, 2019 by americanpharmaceuticalreview