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Category:Finished Dosage > Antibiotics and Antiviral Preparations
Product Name:10% Colistin sulfate soluble powder
Price(USD):0.00
International
Approvals/Standards:GMP
Company:Shandong Huachen Pharmaceutical Co.,Ltd.
Factory Location: Weifang Shandong
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: yes
Payment Terms: T/T
Kelizhuang(10% Colistin sulfate soluble powder)
Polymyxins are a group of basic peptide antibiotics produced by Bacillus polymyxa, including polymyxin A, polymyxin B, polymyxin C, polymyxin D, and polymyxin. Five components, such as E, are narrow-spectrum fungicides. Two kinds of polymyxin B and polymyxin E are commonly used in veterinary medicine.
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【Function and use】
1. It has strong antibacterial ability for almost all Gram-negative bacteria, especially for E. coli, klebsiella, salmonella and pseudomonas aeruginosa. Ineffective against Gram-positive bacteria and fungi.
2. It has a bactericidal action, mainly acts on the bacterial cell membrane, and binds to the free phosphate ester of lipoprotein in the cell membrane, hinders the selective permeability of the cell membrane, strengthens the surface tension and permeability of the cell membrane, and makes the intracellular components, such as excessive leakage of amino acids, purines, pyrimidines, K+, etc., leading to bacterial death.
3. There is almost no problem of drug resistance, and it is particularly pointed out that no R-factor resistance has been found so far. There is cross-resistance between polymyxin B and polymyxin E, but no cross-resistance was found between this class of drugs and other antibiotics.
4. The antibacterial activity of polymyxin B is slightly higher than that of polymyxin E.
5. It is a stationary phase fungicide with a narrow antibacterial spectrum.
【Pharmacokinetics】
Oral is not absorbed. After the injection, it is mainly discharged from the urine, but it is discharged only rarely in 12 hours, and can reach a concentration of 20 to 100 μg/ml later. Continue to have drug excretion within 1~3 days after stopping the drug.
【Indication】
Prevention and treatment of diarrhea caused by Gram-negative bacteria infection.
【Medicine interactions】
Can be combined with other antibiotics, and get multiplied effect, especially with antibiotics acting on Gram-negative bacteria such as bacitracin zinc, flavomycin, sulfonamides, semi-synthetic penicillins (such as amoxicillin), tetracyclines ( such as chlortetracycline and doxycycline), neomycin, etc., the effect is better.
Combined with muscle relaxants and neuromuscular blockers (such as aminoglycoside antibiotics) may cause muscle weakness and apnea.
【Compared with similar preparations】
Table 1 Comparison between Kelizhuang and other like preparations
Items |
Kelizhuang |
Ordinary domestic |
Targeted product |
Raw material |
Highly purified B component |
Mixed component |
Highly purified B component |
Excipients |
Imported |
Domestic |
Imported |
Formulation process |
American Pharmaceutical Technology |
No production process |
Original research process |
Dissolution |
99.2% |
75.5% |
99.1% |
Effect |
Good |
Poor |
Good |
Figure 1 Dissolution comparison of Kelizhuang and domestic similar preparations
It can be seen from Figure 1 that Kelizhuang dissolution rate is significantly better than the domestic similar products.
【Usage and dosage】
Once a dose, piglets 2000~4000u/kg body weight, equivalent to 1mg/kg body weight of this product, 2 times a day.
【Features】
【Precautions】
【Withdrawal time】
Pig 7days
【Storage】
Sealed, shaded, kept in a dry place
【Packing specification】
Specifications: 100g: 10g (300 million units)
Packing: 1000g/bag, 20 bags/carton; 100g/bag, 100 bags/carton
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