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Category:Finished Dosage > Antibiotics and Antiviral Preparations
Product Name:20% Florfenicol Powder
Price(USD):0.00
International
Approvals/Standards:GMP
Company:Shandong Huachen Pharmaceutical Co.,Ltd.
Factory Location: Weifang Shandong
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: yes
Payment Terms: T/T
Fukexin (20% florfenicol powder)
For poultry
|
2.1 Raw material and auxiliary materials
Fukexin used levoflorfenicol as raw material after strict purification process, and its impurities were controlled below 0.2%.
With the addition of imported auxiliary materials, the application of American preparation technology, scientific verification and strict quality control, the accuracy of Fukexin is consistent.
Ordinary florfenicol has the same left-handed and right-handed in the original molecule. Only left-handed is effective. Right-handed is completely useless or even toxic. The absorption rate of left-handed florfenicol is 2-3 times higher than that of ordinary florfenicol, and its activity is 8 times higher than that of right-handed florfenicol.
Florfenicol itself is almost insoluble in water, and domestic preparations can greatly destroy the active ingredients and reduce the curative effect by adding acid, alkali and other cosolvents. Fukexin uses American pharmaceutical technology to make flufenicol fully soluble in water and uniformly distributed, and can ensure 99% non-degradation in water for 12 hours.
Validation of solubility: accurately weigh Fukexin, imported products and domestic products of the same kind 0.3 grams, add 100 ml water (equivalent to 600 grams of pure florfenicol per ton of water) and stir for 30 minutes.
Fukexin uses the process-purified L-florfenicol raw materials and imported excipients, and uses the American pharmaceutical technology to achieve a peak plasma concentration of 1 hour after administration, which is 1.8 times higher than the domestic preparations, so that the florfenicol can be bactericidal action.
Bioequivalence validation: 30-day-old broilers were given the same dose of Fukexin, imported products and domestic products. Blood samples were collected at different time points after administration, and the plasma drug concentration was determined by HPLC.
Fukexin selected the raw material of florfenicol and purified it strictly, which fundamentally solved the problem of residual chloramphenicol and thiamphenicol that customers worried about.
Fukexin residue detection test: Fukxin was given to chickens through water at recommended dosage for 3 days. Chest muscle, liver and kidney were taken from chickens 1, 3, 5 and 7 days after drug withdrawal, and the contents of florfenicol and chloramphenicol were detected respectively. The results are shown in Table 1.
Table 1 Results of the residue test of Fukexin
Drug withdrawal time (days) |
Residual concentration of Florfenicol mg·kg-1 |
Residual concentration of chloramphenicol mg·kg-1 |
||||
Chest muscle |
Liver |
Kidney |
Chest muscle |
Liver |
Kidney |
|
1 |
0.1528 |
0.2756 |
0.2791 |
ND |
ND |
ND |
3 |
0.0892 |
0.1255 |
0.0112 |
ND |
Undetected |
Undetected |
5 |
0.0305 |
ND |
ND |
ND |
||
7 |
ND |
ND |
ND |
ND |
||
Fukexin |
Undetected |
ND |
Note: The detection limit is 10ng•g-1, ND means no detection
Conclusion:
The residues of florfenicol in breast muscle were less than 50 g/kg on the 5th day after discontinuation of Fukexin in poultry for 3 consecutive days. No residues of florfenicol were detected in liver and kidney. No residues of chloramphenicol were detected in breast muscle, liver and kidney on the 1st, 3rd, 5th and 7th day after application of Fukexin.
Table 2 Fukexin usage program
Applicable animal |
Usage and dosage |
Compatible drugs |
Mainly controlled disease |
Chickens |
Water medication: Every 500g of this product dissolves in 2000 kg of water. For 3-5 days |
Neomycin Sulfate, Doxycycline Hydrochloride, Colistin Sulfate, etc. |
Escherichia coli, white diarrhea and typhoid fever |
Ducks |
Escherichia coli disease and infectious serositis in ducks |
Withdrawal time: Pig 20 days; chicken 5 days.
Validity: 2 years
Content: 20%
Packaging and storage: 500g/bottle *12 bottles/box. Keep in a sealed, dry place
Function: It is used to prevent infection caused by sensitive bacteria of pigs and chickens.
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