ADAPALENE

Niksan Pharmaceutical is among world’s top most manufacturer, supplier, exporter and trader of the Adapalene finished formulations moreover Adapalene API. Niksan Pharmaceutical is the huge manufacturer, exporter and supplier of Adapalene API and formulation situated in Ankleshwar, Gujarat, India.

Niksan Pharmaceutical provides API and finished formulations of Adapalene in all over Indian states Like Meghalaya, Tamilnadu, Goa, Sikkim, Assam, Punjab, Delhi, Bihar, Kerala, Gujarat, Haryana, Rajasthan, Madhya Pradesh, Uttar Pradesh, Rajasthan, Karnataka, Jammu Kashmir Etc.

Niksan pharmaceutical is also large exporter of the API and finished pharmaceutical products of Adapalene in many countries for years. The countries where we exporting are Nepal, Sri Lanka, Malaysia, Philippines, Kenya, Singapore, Hong Kong, S.A.R, China, Pakistan, United Arab Emirates, United States, Puerto Rico, Argentina, Egypt, Qatar, Taiwan, China, Algeria, Jordan, Uruguay, United Kingdom, Canada, Bangladesh, New Zealand, Saudi Arabia, Australia, Colombia, France, Vietnam, Ireland, Iraq, Thailand, South Africa, Ecuador, Serbia, Peru, Indonesia, Morocco, Israel, Greece, Romania, Mexico, Iran, Switzerland, Norway, Italy, Denmark, Belgium, South Korea, Netherlands, Venezuela, Hungary, Chile, Sweden, Germany, Ukraine, Spain, Poland, Brazil, Turkey, Russia, Japan and many more countries.

Adapalene is one kind of skin care product. Adapalene belongs to the retinoid like compound. Adapalene used in skin care and works by stopping the pimples from forming under the skin.

SYNONYMS: Adapalene, Adapalènem, Adapaleno, Adapalenum

IUPAC NAME: 6-[3-(adamantan-1-yl)-4-methoxyphenyl] naphthalene-2-carboxylic acid

CAS NO: 106685-40-9

FORMULA: C28H28O3

MOLECULAR MASS: 412.52 g/mol

STORAGE CONDITIONS: Store in cool and dry place, away from direct heat and light.

Do not place in bathroom or kitchen. Keep away from the children and pet.

HOW TO USE: Use this medication on your skin. Wash clean and dry your skin before using the medication. Wash your hands before using the gel, tube or lotion. Do not apply medicine on eyes.

HOW ADAPALENE WORKS: Adapalene works by inhibiting the acne formulation under the skin. Adapalene binds with the retinoid receptor and activates it. Adapalene also use in the beauty care products.

PHARMACOKINETICS: Adapalene absorbed through skin after topical application, used only 2g of 0.3% gel. The half-life of Adapalene 0.3% gel id between 7-51 hours. Almost 25% of drug metabolised in the body. 75% of drug remains unchanged and eliminated by the biliary route.

SIDE EFFECTS: The stinging like sensation occurs after applying the medicine. Side effects like burning, irritation, swelling of skin, itching, dryness of skin, burning are seen in the first 5-6 days of using the medicine. If you see side effects like irritation, intense burning, redness of eye, skin discolouration contact your doctor.

PRECAUTIONS: Before using the medication tell your doctor if you are allergic to Adapalene. Tell your doctor if you have any problem like skin problem, eczema etc. Do not apply this medicine on open wounds. Do not apply on eye or burned part of skin.

CDSCO APPROVAL: Adapalene 0.1% w/w approved by CDSCO in India in 15.03.2001,

Adapalene 0.1% + Benzoyl Peroxide 2.5% gel approved by CDSCO in India in 31.10.2008,

Adapalene + clindamycin gel approved by CDSCO in India in 01.05.2003

FORMULATION AVAILABLE IN MARKET:

Adapalene 0.1% w/w cream

Adapalene 0.1% + Benzoyl Peroxide 2.5% gel

Adapalene + clindamycin gel

Adapalene 0.1% w/w + clindamycin gel 0.1%w/w cream

Adapalene 1%w/w cream

Adapalene 0.1% w/w cream

Adapalene 0.10% w/v gel

Adapalene 0.1% w/w + benzoyl peroxide 2.5%w/w cream

Adapalene 0.02 %w/w + Azithromycin 2 %w/w cream

Adapalene 0.1 %w/v +Allantoin 1 %w/w + Clindamycin 1 %w/w gel

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com 

https://cdscoonline.gov.in 

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult