Amide hydrolase

Due to its unique high catalytic efficiency, high specific selectivity, mild reaction conditions and less waste discharge, bio-enzymes have expanded their practical effects in the pharmaceutical industry, especially in process substitution and greener pharmaceutical processes. It played an important role and its important status was widely recognized. The company has researched and developed a variety of special enzymes for the preparation of chiral intermediates, including carbonyl reductase, alcohol dehydrogenase, transaminase, lipase, acylase, nitrilase and so on. Based on the industrial data feedback from major customers, the total reaction yield increased by more than 10% on average, and the product yield per unit time increased by 40%-50% on average, compared with the original chemical conversion or resolution process. Emissions are reduced by more than 20%.

Enzymatic catalysis has been widely used in the production of heavy drugs such as atorvastatin, rosuvastatin, duloxetine and sitagliptin.

Examples of enzyme application reactions:

R-/S-configuration aminotransferase reaction

Oxidoreductase reaction (KRED/GDH/FDH)

Nitrilase reaction (Nitrilase)