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Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:BOSENTAN
CAS No.:147536-97-8
Standard:ChP, USP, BP, EP, JP, In-house Standards, IP, Ph. Int
Company:NIKSAN PHARMACEUTICAL
Grade: Pharmaceutical Grade
Factory Location: ANKLESHWAR , GUJARAT , INDIA
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Asia,Middle East,Africa
Monthly Production Capacity: 100 KG
Packaging Information: HDPE DRUM WITH LDPE INNER LINNR
Delivery Lead Time: IMMEDIATE
Sample Provided: yes
Payment Terms: L/C
Niksan Pharmaceutical is the largest manufacturer and exporter of the BosentanAPI among all over the world. Niksan Pharmaceutical is one of biggest the supplier, manufacturer, exporter and distributor of the Bosentan API and finished formulations in Ankleshwar, Gujarat, India. The products of Niksan Pharmaceutical and Niksan group companies are widely appreciated by the clients and other companies.
Niksan Pharmaceutical provides API and finished formulations of Bosentan in all over Indian states Like Kerala, Gujarat, Haryana, Rajasthan, Madhya Pradesh, Uttar Pradesh, Rajasthan, Karnataka, Meghalaya, Tamilnadu, Goa, Sikkim, Assam, Punjab, Delhi, Bihar, Jammu Kashmir Etc.
Niksan pharmaceutical is also large exporter of the API and finished pharmaceutical products of Bosentan in many countries for years. The countries where we exporting are Colombia, Iraq, Paraguay, Switzerland, Argentina, Mexico, Pakistan, South Korea, Italy, Germany, Romania, Saudi Arabia, Philippines, Egypt, Spain, Portugal, Australia, United States, Tunisia , Canada, Iran, Turkey, Chile, United Kingdom, 'Taiwan, China', Austria, Netherlands, France, Belgium, Peru, Thailand, Venezuela, Vietnam, Poland, Brazil, Indonesia and many more countries.
Bosentan is the medicine used in the treatment of pulmonary artery hypertension.
Bosentan belongs to endothelin receptor antagonist. Bosentan increase blood flow in patient suffering from PAH.
SYNONYMS OF BOSENTAN:Bosentán, Bosentan, Bosentanum.
IUPAC NAME: 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2(pyrimidin-2-yl) pyrimidin-4-yl] benzene-1-sulfonamide
CAS NO: 147536-97-8
FORMULA: C27H29N5O6S
MOLECULAR MASS: 551.61 g·mol −1
STORAGE CONDITIONS: Store in cool and dry place, keep away from direct heat and light.Do not put in humid place like bathroom.Keep away from children and pet.
HOW TO USE:Take this medicine 2 times per day, normally in morning and evening.
Take medicines by mouth with or without water. Put you tablet in small amount of water and dissolve it, when it dissolves drink whole mixture at once.
HOW BOSENTAN WORKS: Bosentan used in the treatment of pulmonary artery hypertension.It blocks the effects of endothelin and by this Bosentan increase the blood flow in vessels and give relief in PAH (pulmonary artery hypertension)
PHARMACOKINETICS:Bosentan have very low solubility so Bosentan absorbed when it taken in high amount.The drug binds with almost 98% of plasma protein.Bioavaibility of this medicine is 505 and it is not affected by food.Half-life of Bosentan in health person is 5hrs.The Bosentan excited by the biliary excretion.
SIDE EFFECTS OF BOSENTAN: Runny nose, dizziness, flushing and joint pain are the common side effects seen in the patients.If you see symptoms like swelling of ankles, fainting, weight gain, shortness of breath, fast heartbeat, weakness tell your doctor about this problems.This drug can effects on sperm production and also affect your ability to become father.The allergic reaction of Bosentan is rare.
PRECAUTION:Tell your doctor if you have allergic reaction towards the Bosentan.
Talk with your doctor if you have other disease like liver or kidney problems.This rug cause dizziness so kindly avoid driving and heavy exercise.Consumption of alcohol or cannabis can make you dizzier so kindly avoid it while taking the medicament.If you must not be taken in pregnancy because it can harms the unborn baby.
CDSCO APPROVAL: Bosentan (as monohydrate) Tablets 62.5mg/125mg approved by CDSCO in Indian in 23.06.2009.
FORMULATIONS AVAAILABLE IN MARKET:
Bosentan 62.5mg tablets
Bosentan 125mg tablets
Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk
REFERENCES:
www.webmd.com
https://pubchem.ncbi.nlm.nih.gov
https://go.drugbank.com
https://cdscoonline.gov.in
https://www.wikipedia.org/
https://www.drugs.com
https://www.zaubacorp.com
https://www.practo.com/consult
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