DONEPEZIL

Niksan Pharmaceutical is words top leading manufacturer, exporter, trader and supplier of DonepezilAPI as well as finished pharmaceutical products of Donepezilamong the pharmaceutical companies. Our product Donepezilis widely used and appreciated by our group companies and also our customers and users all around the nations. We offer the Donepezilin very affordable price.

Niksan Pharmaceutical provides API and finished formulations of Donepezil in all over Indian states Like Kerala, Gujarat, Haryana, Rajasthan, Madhya Pradesh, Uttar Pradesh, Rajasthan, Karnataka, Meghalaya, Tamilnadu, Goa, Sikkim, Assam, Punjab, Delhi, Bihar, Jammu Kashmir Etc.

Niksan Pharmaceuticalis also large exporters of the API and finished pharmaceutical products of Donepezil in many countries for years. The countries where we exporting are Puerto Rico, United States, Finland, Ireland, New Zealand, Canada, United Kingdom, Belgium, Sweden, Australia , South Korea Austria, 'Hong Kong, S.A.R., China', Singapore, Germany, Philippines, Israel, Italy, Romania, Nigeria, Czechia, Denmark, Switzerland, Norway , Croatia, Greece, 'Taiwan, China', Malaysia, United Arab Emirates , Portugal, Poland, Thailand, Indonesia, Egypt , Iran, Hungary, Brazil, Saudi Arabia, Pakistan , South Africa, France, Turkey, China, Vietnam , Netherlands, Mexico, Colombia, Spain, Japan and many more countries.

Donepezil is the medication used to treat the Alzheimer disease.Alzheimer disease is the condition which causes brain cells to die or waste away and by this Alzheimer’s disease can cause mental disorders and loss of memory.Donepezil belongs to the cholinesterase inhibitors class of medicine.

SYNONYMS: Domepezil, Donepezil, Donepezilo, Donepezilum.

IUPAC NAME OF DONEPEZIL:2-[(1-benzylpiperidin-4-yl) methyl]-5, 6-dimethoxy-2,3-dihydro-1H-inden-1-one. 

CAS NO: 120014-06-4

FORMULA:C24H29NO3

MOLECULAR MASS: 379.49 g/mol

STORAGE CONDITIONS:Store in cool and dry place away from the moisture and sun light.Do not place it in bathroom or humid place.Keep away from children and pets.

HOW TO USE DONEPEZIL:Take this medication with or without food orally.Take our doctors’ advice while writing the prescription.Do not crush, chew or spit the medication.

HOW DONEPEZIL WORKS: Donepezil used in the Alzheimer disease but Donepezil does not cure the disease it is only improve the memory, awareness, and treat confusion.Donepezil inhibits the acetyl cholinesterase enzyme activity and by this process improves the mental condition and brain work.

PHARMACOKINETICS OF DONEPEZIL: Donepezil absorbed slowly by the GI track after the oral administration. Donepezil have 100% bioavaibility and reaches Tmax in 3-4 hours.Almost 96% of Donepezil binds with the plasma protein in the body.The half-life of Donepezil is very high. Donepezil has half-life of 70 hours.Almost 57% of Donepezil eliminated through the urination and only 5% Donepezil eliminated in feces.

SIDE EFFECTS:The common side effects like nausea, vomiting, tiredness, shakiness, muscle cramps, weakness, trouble in sleeping, dizziness are seen in the patients.Tell your doctor if you have effects like black stool, vomit that look like coffee, stomach or abdominal pain, trouble in urination.The allergic reaction is very rare like rash, itching, swelling of tongue, face, trouble in breathing.

PRECAUTIONS:Tell your doctor your medical history if you have intestinal disease like bleeding, trouble in urination, asthma, COPD< fainting, stomach disease etc.Do not take medicine if you are pregnant or in lactation period.This drug has dizziness effect so do not consume alcohol or marijuana while completing the dose.Donepezil cause heart problems so kindly take your doctor’s advice.

CDSCO APPROVAL: Donepezil (for additional indication) approved by CDSCO in India in 10.08.2005, Donepezil HCl. approved by CDSCO in India in 22.03.2001,

Donepezil Hydrochloride Orodispersible Tablet 5mg/10mg approved by CDSCO in India in 15.10.2009,

Memantine 5mg /10mg + Donepezil 5mg Tablets approved by CDSCO in India in 31.01.2008,

Donepezil Sustained Release Tablet 23mg (Modified Dosage Form) 03.06.2011.

FORMULATION AVAILABLE IN MARKET:

Donepezil 5mg tablets

Donepezil 10mg tablets

Donepezil 23mg tablets

Donepezil 5mg + Memantine 5mg tablets

Donepezil 5mg + Memantine 10mg tablets

Donepezil Hydrochloride Orodispersible Tablets 5mg

Donepezil Hydrochloride Orodispersible Tablets10mg

Donepezil HCl tablet

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com