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Email ：PharmaSources@imsinoexpo.com
Whatsapp ：+86-13621645194
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: no
【 Properties 】 This product is colorless to light yellow clear liquid.
【 Pharmacological action 】 Pharmacodynamics Enrofloxacin is a broad spectrum bactericide for fluoroquinolone animals. It has a good effect on Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, portococcus septicus, Staphylococcus aureus, mycoplasma, chlamydia, etc. It has a weak effect on Pseudomonas aeruginosa and streptococcus, and a weak effect on anaerobic bacteria. It has obvious post-antibacterial effect on sensitive bacteria. The antibacterial mechanism of this product is to inhibit bacterial DNA rotation enzyme, interfere with bacterial DNA replication, transcription, repair and recombination, and bacteria can not grow and reproduce normally and die.
Pharmacokinetics The intramuscular absorption of this product is rapid and complete, with a bioavailability of 91.9% in pigs and 82% in dairy cows. It is widely distributed in animals and can enter tissues well. Except cerebrospinal fluid, the concentration of drugs in almost all tissues is higher than that in plasma. The liver metabolism is mainly to produce ciprofloxacin by removing the ethyl of 7-piperazine ring, followed by oxidation and glucuronic acid binding. It is mainly excreted by the kidneys (by renal tubule secretion and glomerular filtration), and 15% to 50% is excreted from the urine in its original form. The elimination half-life varies greatly in different species and different routes of administration. The elimination half-life after intramuscular injection is 5.9 hours in cows, 1.5 to 4.5 hours in sheep, and 4.6 hours in pigs.
【 Drug interaction 】
(1) This product has a synergistic effect with aminoglycoside or broad-spectrum penicillin.
(2) Ca2+, Mg2+, Fe3+, Al3+ and other heavy metal ions can chelate with this product, affecting the absorption.
(3) When combined with theophylline and caffeine, the plasma protein binding rate can be reduced, the concentration of theophylline and caffeine in the blood is abnormally increased, and even the symptoms of theophylline poisoning appear.
(4) This product has the effect of inhibiting liver drug enzymes, which can reduce the clearance rate of drugs mainly metabolized in the liver, and increase the blood drug concentration.
【 Action and use 】 Quinolone antibacterial drugs. For livestock and poultry bacterial diseases and mycoplasma infection.
[Usage and dosage] Intramuscular injection: one dose, 0.025ml per 1kg body weight in cattle, sheep and pigs; Dogs, cats, rabbits 0.025 ~ 0.05ml. Use it once or twice a day for 2-3 days.
【 Adverse reaction 】
(1) Degeneration of cartilage in young animals, affecting bone development and causing lameness and pain.
(2) The reaction of the digestive system is vomiting, loss of appetite, diarrhea, etc.
(3) Skin reactions include erythema, pruritus, urticaria and photosensitivity.
(4) Allergic reactions, ataxia, and seizures were seen in dogs and cats.
【 Note 】
(1) It has a potential excitatory effect on the central system, inducing seizures, and should be used with caution in dogs suffering from epilepsy.
(2) Carnivores and animals with renal dysfunction should be used with caution, which can occasionally cause crystalline urine.
(3) This product is not suitable for dogs before 8 weeks of age.
(4) The drug-resistant strains of this product show an increasing trend and should not be used for a long time at subtherapeutic doses.
[Drug withdrawal period] Cattle, sheep 14 days, pig 10 days, rabbit 14 days.
【 Specification 】100ml:10g
【 Packaging 】
【 Storage 】 Dark, sealed storage.
[Valid period] 2 years
【 Approval number 】
【 Production enterprise 】 Wuhan Liyao Pharmaceutical Co., LTD
Audited Supplier
Pharma Sources Insight JANUARY 2024
