H2B-K120Ub

PEPAKSAPAP KKGSKKAVTK AQKKDGKKRK RSRKESYSVY VYKVLKQVHP DTGISSKAMG IMNSFVNDIF ERIAGEASRL AHYNKRSTIT SREIQTAVRL LLPGELAKHA VSEGTKAVTK(Ub) YTSSK

Description: Synthesized histone H2B peptide corresponding to residues within 1-125 of human histone H2B with monoubiquitination K120 modification.

Application: Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H2B-K120ub is a prominent histone posttranslational modification (PTM) associated with the actively transcribed genome. H2B-K120ub act as a signaling hub for several downstream biochemical processes associated with active transcriptional elongation, including lysine methylation events on histone H3, as well as binding of the histone chaperone complex, FACT.