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High Quality Raw Powder Injectable Prices Lr3 Des Igf1 1mg Lr3-1 Peptide Igf-1lr3 Igf-lr3 Igf-1 Igf 1
Product profile:
IGF (insulin-like growth factors), named for its similarity to insulin, is also known as the "sex hormone medium" (ie SM, somatomedins). It is an active protein polypeptide substance that is necessary for the physiological action of growth hormone. It is now known to include both IGF-1 and IGF-2. (Note: The physiological effects of growth hormone include promoting growth and are essential for sugar, lipid, protein metabolism and inorganic salt metabolism).
Function:
1. Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1).
2. It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) ("long"), for a total of 83 amino acids (relative to the 70 of IGF-1).
3. The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability.
4. As a result, it is approximately three times more potent than IGF-1, and possesses a significantly longer half-life of about 20–30 hours (relative to IGF-1's half-life of about 12–15 hours).
5. The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.