IVERMECTIN

Niksan Pharmaceutical is the largest manufacturer and exporter of the Ivermectinamong all over the world. Niksan Pharmaceutical is one of biggest the supplier, manufacturer, exporter and distributer of the Ivermectin API and finished formulations in Ankleshwar, Gujarat, India. The products of Niksan Pharmaceutical and Niksan group companies are widely appreciated by the clients and other companies.

Niksan pharmaceutical is also large exporter of the API and finished pharmaceutical products of Ivermectin in many countries for years. The countries where we exporting are Bangladesh, Nigeria, Nepal, Ghana, Puerto Rico, Kenya, Philippines, Pakistan, United States, Australia, Lebanon, Ireland, New Zealand, Iraq, Canada, Hungary, Thailand, United Arab Emirates, Serbia, United Kingdom, Vietnam, Dominican Republic, South Africa, Egypt, Germany, Czechia, Austria, Slovakia, Switzerland, Singapore, Denmark, Romania, Ecuador, Israel, Portugal, Malaysia, Peru, 'Hong Kong, S.A.R., China', Croatia, Norway, Sweden, Indonesia, Turkey, 'Taiwan, China', Saudi Arabia, Greece, South Korea, Italy, Iran, Mexico, Colombia, Spain,Brazil, Poland, Netherlands, Belgium, Argentina, Chile, China, France, Russia, Japan and many more countries

Niksan Pharmaceutical provides API and finished formulations of Ivermectinin all over Indian states Like Kerala, Gujarat, Haryana, Rajasthan, Madhya Pradesh, Uttar Pradesh, Rajasthan, Karnataka, Meghalaya, Tamilnadu, Goa, Sikkim, Assam, Punjab, Delhi, Bihar, Jammu Kashmir Etc.

Ivermectin comes in the class called anthelmintic. Ivermectin used to kill parasite like developing the worms inside the body. Ivermectin used in the treatment of head lice, scabies, strongyloidiasis, trichuriasis, ascariasis, river blindness, and lymphatic filariasis.

SYNONYMS:Ivermectin, Ivermectina, Ivermectine, Ivermectinum.

IUPAC NAME: (1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-6-(propan-2-yl)-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclopentacosane]-10',14',16',22'-tetraen-2'-one;

CAS NO: 70288-86-7

FORMULA:C95H146O28

MolecularMASS: 875.1 g/mol

STORAGE CONDITIONS:Store in cool and dry place, keep away from direct light and heat.Do not store in humid place like bathroom or in kitchen.Keep away from children and pets.

HOW TO USE:Take medication 1 hour before the meal one time per day.If you have any confusion related to the medicine, contact to your doctor.

HOW IVERMECTIN WORKS:Ivermectin increase the permeability of the cells of the body, by this process the developing parasites can’t break through the cell wall and by this Ivermectin prevents the parasite infection in the body.

PHARMACOKINETICS OF IVERMECTIN:Ivermectin is lipophilic medicine so it is easily absorbed in the fat medium.Ivermectin does not break through the BBB barriers.Almost 93% OF medicine binds with the plasma proteins.The half-life of the Ivermectin is between the 15-16 hours. Ivermectin metabolizes in liver and only about 1% of medicine excreted through urination.And the remainingmetabolites eliminated by the feces.

SIDE EFFECTS:The common side effects like nausea, vomiting, dizziness, weakness, muscle pain seen in the patient.Contact your doctor if you see some side effects like itching, rash, weakness, joint pain, swelling of limbs.Generally there are some rare side effects like chest pain, itching, fats heartbeat seen in some patients some time.

CDSCO APPROVAL: Albendazole 400 mg + Ivermectin 6 mg tablet approved by CDSCO in India in 25.04.09,

Ivermectin (6mg) tablets approved by CDSCO in India in 2004-June,

Ivermectin concentrate solution/injection approved by CDSCO in India in 1985-October

FORMULATIONS AVAILABLE IN MARKET:

Ivermectin 6mg tablets

Ivermectin 12mg tablets

Ivermectin 3mg tablets

Ivermectin 10 mg tablets

Ivermectin 1% w/w cream

Ivermectin 0.5% w/v solution

Albendazole 400 mg + Ivermectin 6 mg tablets

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult