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Email ：PharmaSources@imsinoexpo.com
Whatsapp ：+86-13621645194
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: no
【 Main ingredient 】 ivermectin
【 Properties 】 This product is a colorless clarified liquid.
Pharmacodynamics Ivermectin mainly has a good repellant effect on nematodes and surface arthropods in vivo. The mechanism of its repellent action is to promote the release of gamma-aminobutyric acid (GABA) from presynaptic neurons, thus opening GABA-mediated chlorine
Ion channels. Ivermectin also has selectivity and high affinity for glutamate-mediated chloride ion channels located near GABA-mediated sites in invertebrate nerve and muscle cells, thus interfering with neuromuscular signal transmission, relaxing and paralysing the worm body, leading to death or expulsion of the worm body. Inhibitory interneurons and excitatory motor neurons are the sites of action in nematodes, while the sites of action in arthropods are neuromuscular junctions. The removal rate of Haemonchodes, Austeria, Cuprea, Trichostrongylus hirschi (including Trichostrongylus eberti), Strongylus, obliquis, fine neck, Trichocephalus, oesophagostoma, dictyura, and adult and fourth stage larvae of Chabot was 97% ~ 100%. It is also effective against arthropods such as maggots, mites and lice. It is slightly less effective against lice chewing and sheep tick flies. Ivermectin is also extremely effective against ticks and flies that breed in their faeces. Although the drug does not kill ticks immediately, it can affect feeding, molting and laying eggs, thereby reducing reproductive ability. The effect on blood flies is similar. The elimination rate of Ascaris, Strongyloides rubrosuis, Strongyloides lamberti, Trichocephalus, oesophagostoma, posterior strongyloides, Coryneus dentatus and immature worm bodies in pigs was 94% to 100%, and it was also very effective against trichinus spiralis in the intestine (but not trichinus spiralis in the muscles), and it also had a good control effect on blood louse and Sarcoptes suis. Not effective against flukes and tapeworms.
The pharmacokinetics of ivermectin vary significantly with different animal species, dosage forms and routes of administration. The bioavailability of subcutaneous injection is higher than that of oral administration, but oral administration is more rapidly absorbed than subcutaneous injection. After absorption, it can be well distributed to most tissues, but it is not easy to enter cerebrospinal fluid. The apparent volume of distribution of sheep and pigs was 4.6L/kg and 4 L/kg, respectively. Most animals have long half-lives, with sheep and pigs ranging from 2 to 7 days and 0.5 days respectively. It is metabolized in the liver and is mainly hydroxylated in sheep and methylated in pigs. It is mainly excreted in the stool, and less than 5% is excreted in the urine as the original form or metabolite. In lactating females up to 5% of the administered dose is excreted from the milk.
Drug interaction: When used in conjunction with ethylamine, severe or fatal encephalopathy may occur.
【 Function and use 】 Macrolide antiparasitic drugs. It is used to control nematodes, acariasis and parasitic insect diseases of sheep and pigs.
[Usage and dosage] For internal administration: one dose, 0.67ml per 10kg body weight; Pig 1.0ml.
[Adverse reactions] No adverse reactions have been observed according to the prescribed usage and dosage.
【 Note 】
(1) Sheep that produce milk for human consumption shall not be used during lactation.
(2) Use with caution in sows 45 days before pregnancy.
(3) ivermectin is highly toxic to shrimp, fish and aquatic organisms. Packaging and containers of residual drugs should not pollute water sources.
[Drug withdrawal period] Sheep 35 days, pig 28 days.
【 Specification 】 0.3%
[Packaging] 500ml/ bottle, 32 bottles/box
【 Storage 】 Keep in a cool, dark and dry place.
[Valid period] 2 years
[Approval number] Veterinary Medicine 170616293
【 Production enterprise 】 Wuhan Liyao Pharmaceutical Co., LTD
Audited Supplier
Pharma Sources Insight JANUARY 2024
