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Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:Livagen (Lys-Glu-Asp-Ala)
CAS No.:/
Standard:USP, Ph. Int
Price(USD):Negotiable
Company:Wuhan Senwayer Century Chemical Co.,Ltd
Grade: Pharmaceutical Grade
Factory Location: Wuhan
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Monthly Production Capacity: 1 ton
Contract Manufacturing: CRO,CMO
Packaging Information: 1kg per foil bag,25kg per drum
Delivery Lead Time: 1 week
Sample Provided: yes
Payment Terms: L/C
Product name | Livagen(Lys-Glu-Asp-Ala) |
CAS No. | N/A |
MF | C18H31N5O9 |
MW | 461.47 |
It is stated that Livagen (Lys-Glu-Asp-Ala) is a weakly hydrolyzed peptide. Peptide hydrolases of small intestine do not hydrolyze Livagen even to a small extent. Under in vitro conditions Livagen reduces glycil-L-leucinedipeptidase activity in small intestine by 50%.Livagen induced activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin, and release of genes repressed due to age-related condensation of euchromatic regions in chromosomes. Our results indicate that Livagen causes de-heterochromatinization (activation) of chromatin, which is realized via modification of heterochromatin and heterochromatinized regions in chromosomes from old people.Livagen proved to be more efficient also as compared to well-known peptidase inhibitors such as puromycin, leupeptin, and D-PAM. The dose-inhibitory effect curves for Livagen and Epitalon were plotted; their IC50 equaled 20 and 500 microM, respectively.
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