Lovastatin

Name: Lovastatin
Availability: lovastatin-19088.html

Category:Active Pharmaceutical Ingredients > Cardiovascular System Drugs
Product Name:Lovastatin
CAS No.:75330-75-5
Standard:USP, BP, In-house Standards
Price(USD):0.00
Company:Archer (Ningbo) Biopharm Co., Ltd.

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Basic Info

Grade: Pharmaceutical Grade

Factory Location: Ningbo,Zhejiang,China

Main Sales Markets: Central/South America,Asia,Middle East,Africa
Sample Provided: no

a cholesterol lowering agent Lovastatin is a cholesterol lowering agent isolated from a strain of Aspergillus terreus.

Lovastatin is a white, nonhygroscopic crystalline powder that is insoluble in water and sparingly soluble in ethanol, methanol, and acetonitrile.

After oral ingestion, lovastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. This is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate limiting step in the biosynthesis of cholesterol.

Chemical Properties White Solid

Usage An antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase

Biological Activity Potent, competitive inhibitor of HMG-CoA reductase (K i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro .

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Lovastatin

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