PVP K Homopolymer (K15/K17/K25/K30/K90)

Category:Excipients > Fining Agent
Product Name:PVP K Homopolymer (K15/K17/K25/K30/K90)
CAS No.:9003-39-8
Standard:ChP, USP
Price(USD):0.00
Company:Archer (Ningbo) Biopharm Co., Ltd.

Basic Info
  • Grade: Chemical Grade

    Factory Location: China Zhejiang Ningbo

    Main Sales Markets: Central/South America,Asia,Middle East,Africa

  • Sample Provided: no

     

    Characters: White powder and transparent solution, soluble in water and numbers of organic solvents, low toxicity, well film forming, good chemical stability and physical inertia and bonding capacity

    Quality Standard:CP.Ph.EP.,USP/NF.BP.

     

    Povidone

    K12

    K15

    K17

    K25

    K30

    K60

    K90

    Appearance

    White or off-white powder

    K value

    10.2-13.8

    12.75-17.25

    15.3-18.36

    22.5-27.0

    27-32.4

    54-64.8

    81-97.2

    N-Vinylpyrrolidone
    (Impurity A)

    (CP2005/USP26) %max

    0.1

    0.1

    0.1

    0.1

    0.1

    0.1

    0.1

    (USP35/EP7/BP2011) ppm max

    10

    10

    10

    10

    10

    10

    10

    Moisture % max

    5.0

    5.0

    5.0

    5.0

    5.0

    5.0

    5.0

    Solid content % min

    95

    95

    95

    95

    95

    95

    95

    pH value(5%in aqueous solution)

    3.0-5.0

    3.0-5.0

    3.0-5.0

    3.0-5.0

    3.0-5.0

    4.0-7.0

    4.0-7.0

    Sulphate Ash % max

    0.1

    0.1

    0.1

    0.1

    0.1

    0.1

    0.1

    Nitrogen content %

    11.5-12.80

    11.5-12.80

    11.5-12.80

    11.5-12.80

    11.5-12.80

    11.5-12.80

    11.5-12.80

    2-Pyrrolidone (Impurity B) % max

    3.0

    3.0

    3.0

    3.0

    3.0

    3.0

    3.0

    Aldehyde(as acetaldehyde) ppm max

    500

    500

    500

    500

    500

    500

    500

    Heavy metal (as Pb) ppm max

    10

    10

    10

    10

    10

    10

    10

    Hydrazine ppm max

    1

    1

    1

    1

    1

    1

    1

    Peroxide(As H2O2) ppm max

    400

    400

    400

    400

    400

    400

    400

    Application:

    Povidone K products possess excellent adhesive, film-forming, dispersing and thickening properties,which are widely used in the pharmaceutical industry. They are one of the three main accessory products recognized & approved worldwide.

    General Summarization:

    u       Low molecular weight Povidone K, for use as a solubilizing agent, crystallization inhibitor and suspension stabilizer in injectables and ophthalmic formulations. Such as Povidone K12, K15, K17.

    u       Medium Molecular Povidone K, for use as binder in tablets, capsules and granulers, as a stabilizer for oral suspensions, film-forming agent, soluilizing agent, dispersant for pigments, as an enzyme stabilizer and to imrove bioavailability.e.g.PovidoneK25, K30.

    u       High molecular Povidone K, a highly effetive binder, for us as stabilizer in oral and topical suspensions, as a thickener, hydropilizing agent e.g.PovidoneK60, K90.

    1.         Binder of Tablets: PovidoneK25, K30, K90 all possess high binding strengths, they are suitable for the wet granulation and direct compression of tablets. PovidoneK25 is used more than K30 and K90, due to its low viscosity. Conversely, PovidoneK90 is used less due to its high binding properties.

    2.         Solubilizers, Solventsand Crystallization inhibitors: Low molecular weight PovidoneK12,K15,K17 are intended for use as solubilizing agents, dispersants and crystallization inhibitors, suspension stabilizers for injections and ophthalmic products.

    3.         Dispersant or coprecipitator agent: PovidoneK25 or K30 act as a comilling or coprecipitation agent in drugs which do not dissolve readily, and will greatly improve the dissolutionb rate of the drug. The method used is to mix the Povidone and drug, and then spray this onto a carrier,granulation or tablet.

    4.         Suspension stabilizer: PovidoneK25, K30 andK90 are suitable for the stabilizing of suspensions with a wide range of active ingredients; the results will be improved if PovidoneK90 is used with PolyPovidone.

    5.         Film/sugar Coatings, film formers: Povidone K25,K30 act a film-forming agents, adhesion promoters and pigment dispersers, and are often used as sugar coating and film coating.

    6.         Thickening agents: PovidoneK90 is suitable for use as a thickening agent for aqueous-alcoholic solutions for oral and topical suspensions.

    7.         Pore-former: PovidoneK30 can be applied as pore-former in taste-masking formulations and K90 can be as pore forming agent in medical plastcis.

    8.         Improvement bioavailability, controlled release aid: PovidoneK12,k15,17,K30,K90 can be used to adjust the dissolving speed of some hardly soluble actives.

    9.         Food Fields: PovidoneK25, K30, K60, K90 can be used in dietetic tablets, e.g. Vitamin, dietary fibre tablets, sweeteners.

    10.     Other Applications: capsule flow aid, cleaning fluids for contact lenses, enzyme and sensitive medicines stabilization, cryoprotector.

    Remarks: Povidone is available for Cosmetic/Personal care applications, they are requested subject to special quality and purity controls of the cosmetic/personal care formulations needed.

    Packaging: Fiber drums of 25kg or 50kg with lining of double PE bag
    Storage: Room temperature, dry, dark place sealed.

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