sr9011 Raw Powder CAS 1379686-29-9 SR 9011 with Fast Delivery

Quick Details:

Product Name: SR9011
Cas No.: 1379686-29-9
Synonyms: 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
Formula: C23H31ClN4O3S
Molucelar weight: 479.03524
Mini order: Only 5g, 10g
Package: Super discreet to ensure 100% pass rate
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Lead time: Within 12 hours upon receipt of payment
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Shipping time: 3-7 days by express door-to-door

SR9011 Application:

SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism.

Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure.

Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic

Recommended Dosage:

The optimal dosage range is 20 to 30 milligrams (mgs) per day. However, there is a downside - due to the short half-life, you need to exclude the entire day in order to get the best balance of actives in the body. Therefore, it is best to use the anesthetic every 2-4 hours, depending on the exact dose used. For example, at a daily dose of 30 milligrams, take 10 milligrams every 4 hours.