Temoporfin

Temoporfin(KW-2345)
CAS: 122341-38-2
Formula: C₄₄H₃₂N₄O₄                        
Molecular Weight:  680.75
 Chemical Name: 8-Dihydroporphyrin-5; 3,3',3'',3'''-(7,8-Dihydroporphyrin-5,10,15,20-tetrayl)tetraphenol; 5,10,15,20-Tetra(m-hydroxyphenyl)chlorin
Biological Activity: Temoporfin is a synthetic light-activated chlorin with photodynamic activity. Upon systemic administration, temoporfin distributes throughout the body and is taken up by tumor cells. Upon stimulation of temoporfin by non-thermal laser light (at 652 nm), and in the presence of oxygen, this agent produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to tumor cells. This may kill tumor cells and may reduce the tumor size. Temoporfin(KW 2345) used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck.Patients can remain photosensitive for several weeks after treatment.