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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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The research on the biological stability of drugs is mainly limited to the anti-enzymatic hydrolysis ability of biological agents such as proteins, peptides and enzymes. For example, l-asparaginase is one of the earliest protein macromolecular biochemical drugs, which is mainly used in acute lymphoblastic leukemia.However, as a kind of enzyme protein preparation, the stability of the drug affects and limits its clinical application to a certain extent.The thermal stability and antitrypsin hydrolysis ability of l-asparaginase -cd inclusion compound were studied after lyophilization. The results showed that -cd can significantly increase the stability of drug and is a good enzyme protectant.Cyclodextrin protein drugs protection reasons might be: protein molecular surface distribution of polar amino acid residues, the polarity of these residues side chain with beta CD molecules form hydrogen bond of hydroxy, thus embedded in the beta CD's mouth water, or residue side chain insert beta CD internal tubular structure, side chain alkyl chain in the hydrophobic bonding and beta CD molecular interactions, the hydrophobic portion of space hole side chain at the same time outside the polar groups and beta CD molecules at the mouth of the close water to form hydrogen bond, forming a stable clathrate.In addition, cyclodextrin can also solve the biological products in water easy to form a dimer, polymer, or easy to be the container wall non-specific adsorption caused by the biological sample activity reduction and other problems. |
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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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Hydroxypropyl Betadex oral grade USP Standard
Product Name: Hydroxypropyl Betadex
Synonyms: Hydroxypropyl Beta Cyclodextrin;
Hydroxypropyl-β-Cyclodextrin.
CAS#: 128446-35-5
EINECS: 420-920-1
DMF NO.: 030168
Quality: Pharmaceutical Grade
Standard: USP,EP,CP
Characteristics & Applications:
Hydroxypropyl Betadex Hydroxypropyl Beta Cyclodextrin can increase solubility and bioavailability of insoluble drugs, so that the efficacy of drugs can last longer with less ingestion of drugs. It can adjust and control drugs release ratio, decrease side effects of drugs, and enhance stability of drugs. Hydroxypropyl Beta Cyclodextrin can be used for oral medication, injection, mucosal delivery systems (including the nasal mucosa, rectum, cornea, etc. ), dermal drug delivery systems, lipophilic drugs targeting delivery, and also used as protective agent and stabilizer of protein.
Specifications:
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CAS No
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128446-35-5
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Molecular Formula
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C42H70-nO35(C3H8O2)n
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Molecular Weight
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1134.98+58n
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Appearance
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White or almost white, amorphous or crystalline powder. Freely soluble in water and in propylene glycol
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Molar Substitution
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0.40~1.50
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Betadex
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≤1.5%
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TAMC (cfu/g)
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≤1000cfu/g
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TYMC (cfu/g)
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≤100cfu/g
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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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Hydroxypropyl-Beta-Cyclodextrin Cosmetic grade /USP Standard
Name: Hydroxypropyl-Beta-Cyclodextrin Cosmetic grade
Item No.: BZZY-004
CAS NO. : 128446-35-5
Standard: USP Standard
Basic information
Product Name : Hydroxypropyl-Beta-Cyclodextrin
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Synonyms : Hydroxypropyl-β-Cyclodextrin
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MF : C42H70-nO35(C3H8O2)n
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MW : 1134.98+58n
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Product Specification of Hydroxypropyl-Beta-Cyclodextrin
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Test Standard
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USP42-NF37
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ITEMS
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SPECIFICATION
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Molar Substitution
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0.40-1.50
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Clarity of solution
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50%(w/v) water solution is clear
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Identification(IR)
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same absorption bands as USP Hydroxypropyl Betadex RS
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Loss on Drying
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≤10.0％
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Conductivity
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10%(w/v) water solution ≤200µS/cm
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Propylene oxide
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≤1ppm
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Propylene glycol
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≤2.5％
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Sum of Other Impurities
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≤1％
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Betadex
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≤1.5%
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Any other single impurity
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≤0.25％
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Heavy Metal
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≤20μg/g
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TAMC(cfu/g)
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≤1000cfu/g
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TYMC(cfu/g)
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≤100cfu/g
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Bacterial endotoxins (EU/g)
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Pharma Sources Insight July 2025
