Niksan Pharmaceutical is one of the leading manufacturer, supplier and exporterof the Silodosin. The best product manufactured by Niksan Pharmaceutical is Silodosin. We manufacture, supply and export best quality product of Silodosin API along withSilodosinformulations. Niksan Pharmaceutical provides best quality product of Silodosin in all states of India like Kerala, Punjab, Rajasthan, Telangana, Bihar, Karnataka, Jammu and Kashmir, Maharashtra, West Bengal, Uttar Pradesh, Gujarat, Delhi, Tamil Nadu, Odisha, Madhya Pradesh, Andhra Pradesh, Haryana and many other states. Niksan Pharmaceutical is also manufacture and exports large quantity of Silodosin products in whole globe since many years in countries like Nepal, Taiwan,China, United Arab Emirates, Bangladesh, Iraq, Ireland, South Korea , Canada, Egypt, Indonesia, United States, Thailand, Philippines, Turkey, Nigeria, Australia, Germany, Malaysia, Vietnam, Spain, United Kingdom, Poland and many more countries. Silodosin belongs to the alpha-blocker class of medicine. Silodosin used in the treatment of enlarged prostate. ENLARGED PROSTATE: Enlarged prostate cause difficulty in urination, pain full urination ad also cause trouble in urine urgency. Silodosin also called alpha-adrenoceptor antagonist which is used in the treatment of BPH. SYNONYMS: Silodosin, Silodosina. IUPAC NAME: 1-(3-hydroxypropyl)-5-[(2R)-({2-[2-[2-(2, 2,2- Trifluoroethoxy) phenoxy] ethyll} amino) propyl] indoline- 7-carboxamide CAS NO: 160970-54-7 FORMULA: C25H32F3N3O4 MOLECULAR MASS: 495.534 g/mol STORAGE CONDITIONS: Store in cool and dry place, away from light and heat. Do not put it in fridge or in bathroom. Keep away from children and pet. HOW TO USE: Take Silodosin tablet/capsule orally with food one time per day. Take doctors’ advice before taking medicine. Silodosin comes in capsule so do not chew it or don’t open it. HOW SILODOSIN WORKS: Silodosin blocks the alpha A1 receptors which located in urethra and bladder. By blocking these receptors Silodosin relaxes the smooth muscles and by this process the flow of urination improves. PHARMACOKINETICS OF SILODOSIN: Normally Silodosin absorbed by the gut. The AUC and peak plasma level may effected by the food. The bio avaibility of Silodosin is 32%. The metabolism of Silodosin is done in liver. The half-life of Silodosin is approximately 13.3±8.07 hrs. The rout of elimination of Silodosin is renal 33.5% and by faecal 54.9%. SIDE EFFECTS OF SILODOSIN: The side effects of Silodosin are ejaculation problem, fainting, headache, dizziness, light headedness. If you have side effect like fainting or weakness contact your doctor and take advice. There are some rare side effects like rash, allergy, and redness of skin, itching or trouble in breathing. PRECAUTIONS OF SILODOSIN: Tell your pharmacist if you have any allergic reaction to the Silodosin. Also tell your doctor if you have any disease related to lung, heart, liver or kidney. Do not drive or use any machinery because Silodosin makes you dizzy. Take less amount of alcohol and also if you are using cannabis talk to your doctor about using it CDSCO APPROVAL: Silodosin Capsules2mg/4mg/8mg approved by CDSCO in India in 23.06.2011 Silodosin Tablets 4mg approved by CDSCO in Indian in 10.04.2012 FORMULATIONS AVAILABLE IN MARKET: Silodosin 2 mg capsules Silodosin 4mg capsules Silodosin 8mg capsules Silodosin 4 mg tablets Silodosin 8 mg tablets Silodosin 4mg + Dutasteride 0.5mg tablets Silodosin 8mg + Dutasteride 0.5mg tablets Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk. REFERENCES: www.webmd.com https://pubchem.ncbi.nlm.nih.gov https://go.drugbank.com https://cdscoonline.gov.in https://www.wikipedia.org/ https://www.drugs.com https://www.zaubacorp.com https://www.practo.com/consult |