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Hangzhou Dingyan Chem Co., Ltd
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| CAS:100403-19-8 EINECS： 309-560-3 |
appearance
Light brown liquid
smell
Special cereal flavor
PH
4.5-6.5
Density (g/ml)
0.9000-1.3000
Bacterial count (CFU/g)
100 or less
Pathogenic bacteria
May not be detected
Moisture content (%)
95.0 or less
barrier
Grubauer et al. used acetone and other organic solvents to treat the skin of male hairless mice aged from 1 to 3 months to study the relationship between skin barrier function and skin lipids.
Holleran et al. studied the relationship between epidermal barrier function and the synthesis of sphingolipids by infiltrating [3H]H20. The results showed that when the skin of hairless mice was treated with acetone to cause skin barrier dysfunction, the synthesis of sphingolipids increased. After 24 h, skin barrier function returned to normal, and nerve sheath lipid synthesis also returned to normal. Therefore, ceramides play an important role in maintaining skin barrier function.
Adhere to
Ceramides bind to proteins on the surface of cells by means of ester bonds, an interaction known as lipid-cell-protein encapsulation. Smith et al. have reported that the degree of adhesion between keratinocytes can be determined by the content of ceramide in the cuticle of the epidermis. The decrease of the content of ceramide in the cuticle of the epidermis can reduce the adhesion between keratinocytes, resulting in dry, desquamated and scaly skin.
Pawlmgs et al. studied the desquamation mechanism of dry skin and found that the main cause of skin dryness was the decrease of ceramide content in the cuticle of the epidermis, and the content of ceramide was directly related to the degree of skin dryness. The use of ceramide can significantly enhance the adhesion between keratinocytes, improve the degree of skin dryness, reduce the phenomenon of skin descaling. Mary kay essence oil with this ingredient.
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Sinoway Industrial Co. Ltd
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Product name
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Ceramide
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CAS No.
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100403-19-8
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Sieve Analysis
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100% pass 80 mesh
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Assay
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1%, 5%, 10%, 30%, 90%, 98%
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Source
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Rice bran, Wheat germ, Soybean, Konjac
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Appearance
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White to light yellow powder
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Item
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Specification
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Results
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Appearance
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white to light yellow powder
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Complies
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Odor
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Characteristic
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Complies
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Activity
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10%
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10.8%
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Sieve Analysis
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100% pass 80 mesh
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Complies
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Ash
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≤1.0%
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0.37%
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Loss on Drying
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≤3.0%
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1.55%
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Heavy Metal
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10ppm Max
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Complies
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As
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2ppm Max
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Complies
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Pb
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2ppm Max.
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Complies
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Microbiology
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Total Plate Count
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1000/g Max
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Complies
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Yeast & Mold
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100/g Max
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<10cfu/g
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E.Coli
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Negative
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Complies
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Salmonella
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Negative
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Complies
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Conclusion
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Conform with specification
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What is ceramide?
Ceramide is a family of lipid molecules. A ceramide is composed of sphingosine and a fatty acid. Ceramides are found in high concentrations within the cell membrane of cells. They are one of the component lipids that make up sphingomyelin, one of the major lipids in the lipid bilayer. Ceramide can actually act as a signaling molecule. The most well-known functions of ceramides as cellular signals include regulating the differentiation, proliferation, programmed cell death (PCD), and apoptosis (Type I PCD) of cells.
Function of ceramide
1.Moisturizing effects
Ceramide has a strong ability of association of water molecules, it is to maintain the moisture of the skin through the mesh structure formed in the stratum corneum.
Ceramide can form a network structure in the stratum corneum water molecules in association to maintain skin moisture. Therefore, ceramide skin has a strong moisturizing effect.
2.Anti-aging effects
Skin aging process, lipid synthesis decreased ceramide content in the stratum corneum decrease the performance of dry skin, scaling, rough and dull; make use of ceramide in the stratum corneum ceramide levels increased, dry skin can be improved, scaling, roughness and other symptoms; Meanwhile, ceramide can increase the thickness of the stratum corneum, improve water-holding capacity of the skin, reduce wrinkles, increase skin elasticity, delay skin aging.
3.Anti-allergic effects
Cause of skin allergies are manifold. According to official reports, by the skin allergy skin care and beauty cosmetics caused more than 70%.
Application of ceramide
- Anti-inflammatory Drugs, pain, antithrombotic, ultraviolet radiation, anti-free radical and immune function of human body
- Treatment of those diseases such as coronary heart disease, cerebrovascular disease, vasculitis, leukopenia and thrombocytopenia
- Used in the food, cosmetic, mainly as an antioxidant . |
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Pharma Sources Insight January 2025
