Chongqing Xingcan Pharmaceutical Technology Co., Ltd
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At present, the conventional preparation process of azo diisobutamidine hydrochloride is generally carried out in three steps: the first step is to oxidize hydrogenated azonitrile to azonitrile with oxidants such as chlorine or hydrogen peroxide; The second step is to carry out the pinner reaction in the presence of methanol and hydrogen chloride to obtain azo imimide Chemicalbook hydrochloride; In the third step, the azo imide hydrochloride is dispersed with alcohol and then ammonia gas is used to obtain azo diisobutamidine hydrochloride. The process has many shortcomings such as long route, difficult to control, and a large amount of wastewater, which is not conducive to environmental protection, and the yield is relatively low, which is not suitable for industrial-scale production. |
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