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Beijing Global Biologicals Co.Ltd
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Aminoglycoside antibiotic G418 108321-42-2 litol 72432-03-2
Specification:
G418 (Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 is produced by fermentation and isolation processes and the G418 producing strainMicromonospora rhodorangea produces many other gentamycins while producing G418. The common impurities of G418 include gentamycin X2, gentamicin A, gentamycin C1, C2, C1a and C2a. The quality of G418 is not based on just the potency, but more on the selectivity defined by the killing curve of the sensitive cells vs the resistant cells. A good G418 product has the lowest LD50 for sensitive cells (such as NIH 3T3) and the highest LD50 (can be up to 5,000 μg/ml) for resistant cells (NIH 3T3 transfected with resistant genes). Gentamycins have almost no selectivity, except gentamycin X2.
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Beijing Global Biologicals Co.Ltd
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Description
Geneticin (G418) Sulfate is an aminoglycoside antibiotic that has originally been derived from Micromonospora rhodoranga NRRL 5326. This compound has been shown to cause a bypass of nonsense mutations during translation. Experiments have shown that geneticin sulfate inhibits the incorporation of amino acids into protein and can destroy fibroblasts. Mechanistic studies suggest that this agent affects the 80S ribosome and inhibits the elongation cycle. Further studies report that geneticin sulfate is highly active against amoebae, protozoa, tapeworm, and pinworm exposed murine cells.
Usage
• Potency: ≥700 μg/mg
Technical Information
| Appearance: |
Powder |
| Physical State: |
Solid |
| Solubility: |
Soluble in water (50 mg/ml) and aqueous buffers. |
| Storage: |
Store at 4° C |
| Boiling Point: |
1012.1 °C at 760 mmHg (Predicted) |
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Pharma Sources Insight July 2025
