ZHEJIANG SACHEM PHARMACEUTICAL TECHNOLOGY CO.,LTD.
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Since its establishment, Zhejiang Saikai Pharmaceutical Technology Co., Ltd. has continuously enhanced its resource integration ability around the pharmaceutical industry chain, built an enterprise-oriented and market-oriented business system, actively identified the key links of the upstream and downstream of the industrial chain, and promoted the overall improvement of the supply chain.
The company has always been committed to opening the international market for small and medium-sized production enterprises. Through the efforts of professional international business team, the company has helped steroid hormone apis and intermediates gain a certain market voice in India. Based on the existing achievements, the company insists on expanding the product line, and has established cooperative relations with many manufacturers in Zhejiang, Hunan, Jiangsu and other provinces. In addition to India, the products are exported to Europe, South America and other overseas regions, and a broad sales market has been established.
Since 2026, relying on the head office to carry out API import, registration and agent procurement business. Under the cooperation of the total company registration team, the company successfully completed the introduction and registration of a number of high-quality apis, and established product cooperation with foreign first-line enterprises, and successfully helped the parent company and domestic pharmaceutical customers related review.
In the future, Sikai Pharmaceutical will forge ahead, do not slack, focus on improving the level of business, to create an excellent corporate brand image. We will make full use of our own advantages, continue to integrate domestic and foreign resources, through strategic cooperation to reach a strong alliance between enterprises, to achieve mutual benefit, mutual assistance and win-win. |
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SHANGHAI JINDUN INDUSTRIAL CO.,LTD
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Product Name: Agomelatine
Cas No.: 138112-76-2
Molecular Formula: C15H17NO2
Formula Weight: 243.3
EINECS No.: 629-727-7
Melting point: 107-109°C
Boiling point: 478.8±28.0 °C(Predicted)
Density: 1.109±0.06 g/cm3(Predicted)
Application: Antidepressant |
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SUZHOU MYLAND PHARM & NUTRITION INC.
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Product name
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Agomelatine
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Other name
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N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide; N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
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CAS No.
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138112-76-2
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Molecular formula
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C15H17NO2
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Molecular weight
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243.3082
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Purity
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99.0%
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Appearance
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White powder
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Packing
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1kg/bag 25kg /drum
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Application
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Health product raw material
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1. Product introduction
Agomelatine was first launched in Europe in 2009 and is now approved for use in more than 70 countries. Unlike traditional antidepressants, agomelatine works by targeting melatonin and serotonin receptors in the brain. By acting as an agonist at melatonin receptors, agomelatine helps normalize the disrupted sleep patterns often associated with depression. This mechanism not only helps improve sleep quality but also helps restore natural circadian rhythms. In addition, agomelatine acts as an antagonist at certain serotonin receptors ( 5-HT2C receptors). This unique dual action indirectly enhances the availability of serotonin in the brain, a neurotransmitter responsible for regulating mood. By regulating serotonin levels, agomelatine can act as an effective antidepressant, relieving symptoms such as sadness, loss of interest, feelings of guilt or worthlessness. Additionally, agomelatine may provide other benefits. Research suggests it may help improve cognitive function Research demonstrates its potential to enhance memory, attention, and executive function, making it an exciting area for future research.
2.Feature
(1) High purity: Agomelatine can obtain high-purity products through natural extraction and refining production processes. High purity means better bioavailability and fewer adverse reactions.
(2) Safety: High safety, few adverse reactions, and the scope of impact is also very small.
(3) Stability: Agomelatine has good stability and can maintain its activity and effect under different environments and storage conditions.
(4) Easy to absorb: Agomelatine can be quickly absorbed by the body.
3. Applications
Agomelatine is an antidepressant and a melatonin antagonist. It reduces depressive symptoms by regulating melatonin MT1 receptors (reduces cortical alarm signals) and MT2 receptors (circadian sleep rhythm) and serotonin levels. Taken at night, it mimics the natural rhythm of melatonin release and can significantly improve sleep quality. Its mechanism of action breaks through the traditional monoamine transmitter system. It activates melatonin receptors MT1 and MT2 and antagonizes 5-HT2C receptors. Improves sleep quality, restores biological rhythm, and has an antidepressant effect; among them, by antagonizing 5-HT2C receptors on the postsynaptic membrane, it can increase the release of DA and NE in the prefrontal cortex, exerting an antidepressant effect. When MT agonism and 5-HT2C receptor antagonism coexist, a unique synergistic effect can be produced, promoting the release of more DA and NE in the PFC brain area, further strengthening the antidepressant effect. In addition, agomelatine can promote the release of brain-derived neurotrophic factor in the PFC and block the stress-induced release of glutamate in the amygdala brain area.
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