Sinoway Industrial Co.Ltd.
|
Product name
|
Eptifibatide acetate
|
Sequence
|
Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2
|
CAS No.
|
188627-80-7 (Eptifibatide (net)),
148031-34-9 (Eptifibatide acetate)
|
Molecular Formula
|
C35H49N11O9S2
|
Molecular Weight
|
832.4
|
Molecule Structure
|
|
Quality Standard
|
98% up by HPLC, GMP
|
Appearance
|
White slightly yellwish powder
|
COA of Eptifibatide Acetate
|
Items
|
Specification
|
Results
|
Appearance
|
White slightly yellwish powder
|
Conforms
|
Purity(HPLC)
|
> 98%
|
99.57%
|
Peptide
|
≥ 80%
|
|
Amino acids
|
Asp:0.85-1.15
Cys:0.75-1.15
Gly:0.85-1.15
Pro: 0.85-1.15
Har: 0.85-1.15
Trp:Present
|
1.08
1.00
0.98
1,06
1.07
|
Specific optical rotation
|
-53- -57°(C=5, 1% Acetic acid)
|
-55.6°
|
Solubility
|
Soluble in water and 1% acetic acid at a concentration of ≥ 1mg/ml to give a clear, colorless solution
|
Conforms
|
Related substances (HPLC)
|
Total impurities: ≤ 1.5%
Any impurity: ≤ 1.0%
|
0.6%
0.2%
|
Water (Karl Fischer)
|
≤ 5.0 %
|
3.8%
|
Acetic acid (HPLC)
|
≤ 10.0%
|
8.7%
|
Bacterial endotoxins
|
< 10EU/mg
|
Conforms
|
Mass balance
|
95.0%-105.%
|
98.11%
|
DMF (GC)
|
≤0.088%
|
Conforms
|
can
|
≤0.041%
|
Conforms
|
Conclusion
|
Complies with the standard.
|
Function of Eptifibatide acetate
Eptifibatide acetate is a cyclic heptapeptide, a glycoprotein IIb/IIIa receptor inhibitor, and has antiplatelet activity.
Application of Eptifibatide acetate
Eptifibatide acetate is used for the treatment of acute coronary syndrome (unstable angina pectoris/non-ST-elevation myocardial infarction), including patients who will receive medical treatment or who are planning to undergo percutaneous coronary intervention (PCI).
|
Send Inquiry
|