Sinoway Industrial Co.Ltd.
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Product name
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Nilotinib
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CAS No.
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641571-10-0
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Molecular Formula
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C28H22F3N7O
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Molecular Weight
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529.523
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Quality Standard
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99% up by HPLC
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Appearance
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White to pale yellow powder
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Function of Nilotinib
Nilotinib is improved from the molecular structure of imatinib, and has stronger selectivity for BCR-ABL kinase activity, and its inhibitory effect on tyrosine kinase is 30 times stronger than that of imatinib, which can inhibit Kinase activity of imatinib-resistant BCR-ABL mutants, while also inhibiting KIT and PDGFR kinase activities. For the treatment of chronic myeloid leukemia (CML), a life-threatening blood cancer that is refractory to or intolerable to imatinib mesylate. Based on a pivotal Phase II clinical study design evaluating the positive results of oral nilotinib in clinical trials against imatinib mesylate or in patients with Ph+ CML in the slow and accelerated phases of apparent toxicity: High efficacy, good tolerance, and manageable safety.
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Lewoo Pharmatech(Shanghai)Co.,Ltd
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C28H22F3N7O
Nilotinib
Nilotinib(AMN107);Nilotinib,AMN107,Tasigna;Nilotinib-d6;4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-phenyl)-3-((4-(pyridin-3-yl)pyrimid;Nilotinib&aMp;4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(Chemicalbook4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamideNilotinib(AMN-107);Nilotinib4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide;Nilotinib,>=99% |
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