Antioxidant property of ellagic acid inclusion complex prepared by cyclodextrins

Ellagic acid inclusions were prepared using ellagic acid(EA) with β-cyclodextrin (β-CD), hydroxypropyl- β-cyclodextrin (HP-β-CD), dimethyl- β-cyclodextrin (DM-β-CD), sulfobutyl- β-cyclodextrin (SBE-β-CD), The binding rate of tannagic acid inclusion was also determined using HPLC, The envelopes were then characterized by Fourier infrared spectra, X- -ray diffraction, and SEM, The evaluation of ellagic acidcompounds by free radical scavenging capability, The apparent solubility of the EA/β-CD, EA/HP-β -CD, EA/DM-β -CD, EA/SBE-β -CD package was 0.0373mg/mL, 0.1232 mg/mL, 0.0938 mg/mL, 0.0956 mg/mL,, respectively The inclusion rate was 82.58%, 89.80%, 87.42%, and 84.64%, respectively.

The half clearance (EC50) value of tannagic acid and four ellagic acidcompounds was 6.47 ug/mL, 6.31ug/mL, 3.45 ug/mL, 3.63 ug/mL, 3.92 ug/mL; The EC50 value for clearing the ABTS radical was 13.53 ug/mL, 12.11ug/mL, 7.00 ug/mL, 7.66 ug/mL, 7.77 ug/mL;, respectively The EC50 value that cleared the hydroxyl radicals was 0.1336 ug/mL, 0.1363 ug/mL,0.1082ug/mL,0.1083ug/mL,0.1055ug/mL; respectively The EC50 value of the cleared superoxide anion radicals was 89.41ug/mL, 59.71 ug/mL, 55.20 ug/mL, 58.32 tg/mL, 55.29 ug/mL., respectivelyThe results show that the coating technique can improve the solubility and antioxidant capacity of ellagic acid.

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. is a high-tech enterprise focusing on the research and development, production and application of cyclodextrin derivatives, cyclodextrin wrapping compounds and new cyclodextrin materials.The main products include Hydroxypropyl beta cyclodextrin (HPBCD, CAS128446-35-5), Betadex Sulfobutyl ether sodium (SBECD, CAS182410-00-0) ,
Methyl beta cyclodextrin (MBCD, CAS 128446-36-6),
Hydroxypropyl gamma cyclodextrin (HPGCD, CAS 128446-34-4) etc..company production, testing equipment complete, built 2000 ㎡ high standard GMP workshop and 2000 ㎡ research and development, testing, pilot laboratory, inspection instruments including Seymerfei ion chromatograph, Beckman capillary chromatography, Shimjin gas chromatograph and liquid spectrometer, infrared spectrometer, photometry, can meet the independent detection of all projects from the raw materials to the factory.