Application of cyclodextrins in increasing the physical stability of drugs

At present, cyclodextrin in increased physical stability of drugs is the most widely used drugs in the preparation of volatile emission reduction in the process of production and storage. As with the betacyclodextrin of cinnamon oil, Styrax and curcuma oil inclusion, the volatility significantly reduced the stability of surface. The inclusion of menthol with hydroxypropyl - cyclodextrin can prevent volatilization and sublimation, and the development of its preparation. Borneol betacyclodextrin inclusion has been applied to improve the quality of Compound Salvia Tablet and hemorrhoids ointment, the study found that the inclusion of borneol can not only prevent volatilization, increase stability, improve the solubility of agents can also use drug absorption and curative effect, and the preparation process has been in operation. In addition, in the preparation of drugs exist polymorphs, to pack it with cyclodextrin, may also prevent conversion of the crystal forms of drugs, to ensure drug effect.
Borneol betacyclodextrin inclusion, borneol with resuscitative, antipyretic analgesic effect, due to its easy sublimation, resulting in the preparation process and the storage period is very unstable, with betacyclodextrin inclusion, the good light and heat stability, moisture stability and significantly increased to prevent volatile.
Artificial musk betacyclodextrin inclusion, artificial musk because it contains a large number of volatile components, resulting in the loss of easy preparation and storage process, affecting the development of formulation and efficacy of containing artificial musk preparation stability, so the artificial musk and beta cyclodextrin inclusion compound refined to improve its stability, for the development and improvement of formulations containing artificial musk and ensure clinical effect and stability lay a certain foundation.