Effective Utilization of Hydroxypropyl Bettercyclodextrin in Inclusion of Chlorogenic

Effective Utilization of Hydroxypropyl Bettercyclodextrin in Inclusion of Chlorogenic Acid Chlorogenic acid is one of the main antibacterial and antiviral effective pharmacological components of Flos Lonicerae . The semi - hydrate is needle - like crystal ( water ) , and becomes anhydrous compound at 110 ℃ . The solubility in water is 4 % in 25 ℃ , and the solubility in hot water is greater . It is easy to dissolve in ethanol and acetone . It is very slightly soluble in ethyl acetate . chlorogenic acid is a kind of important bioactive substance , and has the functions of resisting bacteria , resisting virus , increasing leukocyte , protecting liver , benefiting gallbladder , resisting tumor , lowering blood pressure , reducing blood fat , scavenging free radicals and stimulating central nervous system . Hydroxypropyl beta - cyclodextrin was produced by Shandong Zhiyuan Bio - Tech Co . , Ltd . Its water solubility is good . It has a significant solubilizing effect on the water - insoluble drug . Hydroxypropyl β - cyclodextrin - chlorogenic acid inclusion compound is prepared by liquid phase method . The stability of the inclusion and free chlorogenic acid aqueous solution is investigated . The results show that the thermal stability and chemical stability of chlorogenic acid are increased . Hydroxypropyl beta - cyclodextrin inclusion of chlorogenic acid makes it possible to improve the effective utilization of chlorogenic acid in the field of medicine , reduce the use cost , and improve the production process and develop more effective use technology .