Highly effective antibacterial peptide polymer mimicking host defense peptide for chronic ulcer infe

Host defense peptides exist in the body's first line of defense, and have many functions such as anti infection and immune regulation. As a host defense peptide mimic, can antibacterial β - peptide polymer have anti biofilm and immunomodulatory effects according to molecular design scheme, and be used in chronic infection industry? Recently, the research group of Professor Liu Runhui of East China Science and technology has explored and discovered a β - peptide polymer with high efficiency of anti biofilm and immune regulation.

It is very difficult to eradicate diffuse ulcer infection. Many antibiotics are needed to remove the biofilm in this kind of infection, which makes the way of high antibiotic resistance more and more serious. In addition, the continuous inflammatory reaction in diffuse ulcer infection blocks the rational healing of ulcer.

The β - peptide polymer developed by Professor Liu Runhui's research group is resistant to MRSA of Staphylococcus aureus The removal rates of mature biofilms formed by USA300 and Pseudomonas aeruginosa lesb58 reached nearly 80%. It was found that the polymer exhibited a concentration dependent immunoregulation function under the stimulation of lipopolysaccharide (LPS) of Pseudomonas aeruginosa. Unlike most host defense peptides, such as LL-37 and IDR polypeptides, the polymer could only inhibit the secretion of inflammatory factors such as TNF - α induced by LPS, but not in a concentration dependent manner.

a:多肽聚合物20:80 Bu:DM抗感染及免疫调节功能研究示意图; b:抗生物膜活性; c:免疫调节功能

In vivo model of ulcer infection in vivo, 5 mg / kg of non subcutaneous toxicity concentration was selected for local administration, peptide polymer 20:80 Bu: DM treatment group showed effective antibacterial activity and good ulcer healing function, and had the potential to deal with chronic infection challenges such as ulcer with biofilm and persistent inflammation which were difficult to cure clinically (Fig. 2)

a:多肽聚合物20:80 Bu:DM抗小鼠溃疡感染模型示意图 （绿脓杆菌）; b:皮下毒性试验；c:在溃疡感染中的愈合功能；d:在溃疡感染中的抗菌活性

At the end:

The highly effective antibacterial peptide polymer of defense peptide is the raw material for peptide production. Gutuo Biotechnology Co., Ltd. is a polypeptide manufacturer specializing in the production of defensive peptides and antibacterial peptides. It also supplies raw materials for defense peptides and antibacterial peptides. Hangzhou gutuo Biotechnology Co., Ltd. is well-known in the field of peptide companies in China. Although the scale of the company is not too large, many difficult peptides can be modified. More importantly, the quality control is strict and the price is reasonable. Companies or scientific research institutions that need to buy antimicrobial peptides are welcome to purchase.

For any requests of Peptide for research purpose, welcome to contact us. www.gtpeptide.com , sales1@gotopbio.com.