Structure，manufacturing process，Indications and bulk purchase etc., of Clobetasol Propionate.
Clobetasol propionate describes a corticosteroid that treats moderate to severe skin infections. It can treat skin infections such as psoriasis, seborrheic dermatitis, contact dermatitis, and eczema. The patient ought to apply the topical corticosteroids on the skin as a crystalline powder, shampoo, ointment, or cream.
Generally, the drug can result in several adverse effects. Thus, it would be best to make sure that the patient applies it for a short period. Also, the drug should be an alternative dosage, specifically where other weaker corticosteroids do not work. Its cream is not recommendable for perioral dermatitis and rosacea.
Clobetasol propionate got launched for medical use in 1978, ten years after it got patented. It is recommendable for patients as a generic medication. In any case, the medicine recorded up to two million prescriptions in 2017 in the US alone.
Clobetasol Propionate Structure
Its CAS number is (25122-46-7), c 25 h 32. The drug is available for all biochemicals, antibodies, and assay kits providers. Generally speaking, it is a potent corticosteroid that treats various skin disorders, including psoriasis and eczema.
The drug features 25 c, chlorinated steroid, a 3-oxo-Delta (4)-steroid, a fluorinated steroid, a glucocorticoid, a 20-oxo steroid, and an 11 beta-hydroxysteroid. These components enable it to work as an anti-inflammatory drug.
Its molecular weight is about 466.97 g/mol and comes in two topical cream forms. The cream forms include emollient cream and regular cream. Well, patients can use emollient creams for moisturizing medications. On the other hand, they can acquire the regular cream with its brand name, Impoyz.
Clobetasol propionate APIs include purified water, sodium hydroxide, carbomer 1342, and mineral oil. They also encompass polyoxymethylene and propylene glycol Hypromellose.
How Does Clobetasol Propionate Work?
The drugs act on the body by enabling it to halt extreme immune system responses. Once it calms down the immune reactions, it allows the body cells turnover rate to slow down radically. Hence, the scaly and itchy rash can improve on the treated skin.
In any case, it may take up to three days before the drug starts working whenever pharmacists advise it to patients with conditions like eczema. But still, the patient may notice symptoms improvement for aspects such as itching, plaque psoriasis, redness, and inflammation in a short period.
Clobetasol Propionate Manufacturing Process
The drug’s manufacturing procedure involves an improved tech production of betamethasone-17-propionate. In general, betamethasone-17-propionate is a clobetasol propionate intermediate. The most crucial step in the process merges two convectional technological methods. These methods include hydrolysis and cyclo-esterification.
Merging these two crucial steps enables the manufacturers to shorten production and improve yield. Also, it allows the procedure to enhance the product purity. It also helps to save auxiliary materials, energy, and raw materials. Above all, it reduces production costs and environmental pollution.
In general, clobetasol propionate is a potent Halogen glucocorticoid medicine. It is suitable for non-infectious and pruritic inflammatory dermatoses. Some common infections include discoid lupus, lichen planus, palmoplantar pustulosis, psoriatic, and neurodermatitis.
Its systemic adverse response is three times of fluocinolone acetonide. On the other hand, its anti-inflammatory reaction is averagely 112 times of hydrocortisone. Most methods that prepare the medicine use Betamethasone Valerate as the raw material through four reaction steps. These four steps include sulfonation, hydrolysis, ting ester, and chlorine.
What Clobetasol Propionate is Used to Treat
The drug is suitable for treating various skin ailments such as lichen, psoriasis, herpes labialis, and chronic eczema. Clobetasol propionate can also treat numerous auto-immune infections such as mycosis fungoides and alopecia areata. It is also the first-line treatment option for chronic and acute GVHD skin disorders.
Dark-skinned women may also apply it for skin whitening, although this application is debatable. Besides, selling the medicine for skin whitening use is illegal, according to the US Food and Drug Administration. Nevertheless, there are numerous skin whitening clobex products available on the market containing clobetasol propionate.
Some countries do not have any clear regulations about its use and sale. Thus, it would be best to caution patients that using the cream to whitening the skin can turn it thin and make it get easily bruised. Above all, it can also result in acne and visible capillaries.
Clobetasol Propionate Price
Clobetasol propionate 0.05% costs about $31 for every 15 grams. Yet, the price may vary from one pharmacy to another, depending on where it is situated. It would be best to mention that the medicine is usually not suitable for insurance plans. Instead, it is apt for cash-paying patients.
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Clobetasol Propionate Side Effects
The drug relates to several side effects. The most common side effects include suppression, oozing, scaly, encrusted, skin rash, skin irritation, soreness, redness, itching, and dry skin.
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Is clobetasol propionate suitable for pregnant women?
The drug is safe for use during pregnancy and breastfeeding, but it would be best to ensure that the patient cleans their hands and breasts properly before breastfeeding. The drug is also safe for young children, but the doctor's advice is paramount.
Do you need to call your doctor to use topical corticosteroids?
Patients can buy the drug over-the-counter. However, it would be best to ensure that they always seek guidance from a qualified physician. Phamasicits should conduct extensive tests to ensure that the medication is safe for any specific patient.
Is it safe to apply clobetasol propionate per day?
A tablespoon of the drug would be enough to cover an entire scalp. Nevertheless, it would be best to ensure that the patient seeks guidance from the doctor. It may be suitable for daily use in some cases and not suitable for others.