Dexamethasone is a synthetic corticosteroid that suppresses the action of your immune system towards various diseases. It thus aids in reducing symptoms such as redness, swelling, and allergic reactions.
What Is Dexamethasone
Dexamethasone is a man-made corticosteroid with potent anti-inflammatory action. It works by binding to certain steroid receptors. It also inhibits apoptotic pathways and NF-kB activation.
This product does not have the self-retaining properties of adrenal-related hormones.
Chemical and Physical Features
CAS Number: 50-02-2
Molecular Formula: C22H29FO5
Melting Point: 504 to 507°F
Appearance: White crystalline powder
Dexamethasone Forms And Specifications
This product can be bought in the following forms:
Dexamethasone Sodium Phosphate
Tobramycin And Dexamethasone
Tobramycin is an antibiotic derived from Streptomyces tenebrarius, which is used to treat a range of Gram-negative bacterial infections, especially those caused by Pseudomonas.
Dexamethasone, on the other hand, is a synthetic corticosteroid mainly used for anti-inflammatory properties.
Dexamethasone Vs. Prednisone
Both dexamethasone and prednisone are synthetic steroids used to suppress inflammation and the functioning of the immune system.
They mimic the action of hydrocortisone — a natural corticosteroid produced by the adrenal glands.
Both the products are effective against various conditions, and it is challenging to determine which steroid is more effective. Usually, dexamethasone is used if the steroid needs to be long-acting. In contrast, prednisone is used if the action needs to be short-acting.
Studies have carried out a head-to-head comparison of these drugs in children with asthma. According to the results, it may be possible that dexamethasone is better tolerated. However, more research is needed to prove the same.
Dexamethasone Mechanism Of Action
Dexamethasone is a man-made adrenal corticosteroid with potent anti-inflammatory and immunomodulatory action.
The short-term effects of the product are decreased permeability of capillaries and vasodilation. It also prevents leukocyte migration to the site of inflammation.
When it binds to the glucocorticoid receptor, it alters gene expression that causes various downstream effects. Glucocorticoids prevent neutrophil demargination and apoptosis.
Other action includes:
Inhibiting NF-Kappa B and inflammatory transcription factors
Promoting anti-inflammatory genes, such as interleukin-10
A higher dose of this product is immunosuppressive, while a lower dose provides anti-inflammatory action.
A high dose of glucocorticoid for a longer duration binds to the mineralocorticoid receptor, decreasing potassium levels, and increasing sodium levels.
Dexamethasone Manufacturing Process
Synthesis of dexamethasone includes the following steps:
Dehydration of 16β-methylprednisolone acetate, which results in the formation of 9,11-dehydro derivative
This product is then treated with a source of hypobromite, such as N-bromosuccinimide
The resultant product is 9α-bromo-11β-hydrin derivative
Now, it is ring-closed to an epoxide
This step is followed by ring-opening with hydrogen fluoride in tetrahydrofuran
What Is Dexamethasone Used For
Dexamethasone reduces inflammation and suppresses the functioning of your immune system.
This action makes the product effective against:
Hormone and blood disorders
Immune system disorders
Effect Against Coronavirus
According to the RECOVERY Trial, dexamethasone enhances the survival rate of patients with COVID‑19 on a ventilator or oxygen.
In September 2020, the World Health Organization allowed the use of dexamethasone for COVID-19.
It is mainly used with azithromycin to treat some hospitalized patients with COVID-19.
Tobramycin And Dexamethasone Ophthalmic Suspension
Tobramycin and dexamethasone suspension is a combination of antibiotic and corticosteroid used to treat inflammatory eye disorders such as eye injury, uveitis, chemical burns, and radiation.
This combination can also be used when there is a risk of bacterial infection of the eye or its surrounding tissues.
Neomycin, Polymyxin B Sulfates And Dexamethasone Ophthalmic Suspension
The combination of these products is used to prevent or treat bacterial infections of the eye or inflammation of the eye.
The products polymyxin and neomycin are antibiotics that prevent or stop bacterial growth. Dexamethasone is a steroid that manages swelling and other signs of inflammation.
The dose of dexamethasone is variable and may differ for different patients with the same condition. The usual dose ranges between 0.75 to 9 mg a day.
Dexamethasone Side Effects
Some common side effects associated with the use of this product is:
Trouble falling asleep
Low potassium levels
High blood pressure
Mood changes, such as depression or personality changes
High blood glucose
Dexamethasone API Bulk Price
The average cost of dexamethasone sodium phosphate is $621/kg. The price may vary depending on the supplier and forms of dexamethasone.
Dexamethasone Manufacturers In China
You can buy dexamethasone through many manufactures in China. Some famous ones include:
Zhejiang Xianju Pharmaceutical Co, Ltd: With excellent services and high technology, Xianju pharma is one of the most well-known manufacturers.
From its establishment in 1972, the company is dedicated to scientific research. They are a leading manufacturer of hormones and steroids in China.
Tianjin Tianyao Pharmaceuticals Co Ltd: It specializes in the import and export of pharma products. They also deal in antibiotic, biochemical medicine,
chemical raw materials medicine, and Chinese patent medicine. They are among the largest manufacturers of dexamethasone.
You can also buy dexamethasone in bulk from PharmaSources.com. You can also find many other suppliers here. It is a vertical e-commerce online destination with many quality global suppliers. PharmSources offers high-quality products to about 211 countries and regions. You can also compare products sold by various distributors and companies and thus make an informed decision.
Frequently Asked Questions
What is Dexamethasone Half-Life?
The half-life depends on the form and dose of the product. The half-life of a 20 mg tablet of dexamethasone is 4 hours, while that of 1.5 mg is 6.6±4.3h. The intramuscular 3mg dose has a half-life of 4.2±1.2h.5
Does dexamethasone work against COVID-19?
Yes. Its use is seen to be effective in patients hospitalized due to COVID-19 and are on ventilation or oxygen. The WHO has also allowed its use for managing certain COVID-19 cases to improve their outcomes.
Dexamethasone injection how long does it last?
The shelf-life of dexamethasone injection ranges between 18-24 months if stored appropriately.
How long does it take for dexamethasone to work?
The duration of action of the product depends on the dose and route of administration. Dexamethasone has a wide therapeutic window, and its dose and action depend on the body’s natural process. In most cases, dexamethasone is used for an extended period, from days to months.