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Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:98.0% up by HPLC Ademetionine 1, 4-butanedisulfonate 101020-79-5
CAS No.:101020-79-5
Standard:ChP
Price(USD):Negotiable
Company:Sinoway Industrial Co. Ltd
Grade: Pharmaceutical Grade
Factory Location: Xiamen
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Monthly Production Capacity: 10tons/year
Contract Manufacturing: CRO,CMO
Packaging Information: 25kg/bag
Delivery Lead Time: 7 days after payment
Sample Provided: yes
Payment Terms: L/C
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Product Information |
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Product name |
Ademetionine 1, 4-butanedisulfonate; |
|
CAS No. |
101020-79-5 |
|
Molecular Formula |
2(C15H23N6O5S).2(C4H10O6S2).C4H8O6S2 |
|
Molecular Weight |
1451.63 |
|
Quality Standard |
Ademetionine: 50.0 - 54.0% by HPLC; 1,4-butanedisulfonate: 46.0%–49.0% by HPLC |
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Appearance |
White to off-white Powder |
|
COA |
|
Test Items |
Specifications |
Results |
|
Appearance |
White to off-white Powder |
White crystalline powder |
|
HPLC |
The retention time of the major peak corresponds to the reference sample. |
Complied |
|
Specific Rotation |
+28° ～ +34° |
+30° |
|
Water |
3.0% MAX |
2.2% |
|
PH (0.4% AQUEOUS SOLUTION) |
1.8 -2.5 |
2.2 |
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Residue on ignition |
≤ 0.5% |
0.3% |
|
Heavy Metals |
Not more than 10 ppm |
Complied |
|
Content of Ademetionine(HPLC) |
50.0 - 54.0% |
50.1% |
|
Content of 1,4-butanedisulfonate |
46.0%–49.0% |
48.6% |
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S,S-isomer |
≥ 60% |
77.5% |
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Related substances(HPLC): |
|
|
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- ADENINE |
0.5% MAX. |
0.1% |
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- S-ADENOSYL-L-HOMOCYSTEINE |
0.5% MAX. |
0.05% |
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- METHYLTHIOADENOSINE |
0.5% MAX. |
0.2% |
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OTHER INDIVIDUAL IMPURITY |
0.1% MAX. |
0.09% |
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- TOTAL OTHER IMPURITIES |
1.0% MAX. |
0.4% |
|
- TOTAL IMPURITIES |
2.5% MAX. |
0.8% |
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ASSAY |
≥ 97.0% |
98.7% |
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Bacterual endtoxin : |
≤ 0.25EU/mg |
Complied |
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Microbiology : |
|
|
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Total Aerobic Count |
≤ 200cfu/g |
Complied |
|
Total Combined Yeasts and Molds Count |
≤ 100cfu/g |
Complied |
|
E. coli |
Absent/10g |
Complied |
|
Conclusion |
Complies with Enterprise standard |
|
|
Usage |
Functions of Ademetionine 1,4-Butanedisulfonate
Ademetionine 1,4-butanedisulfonate (SAMe-1,4-BDS) is a stable salt form of S-adenosylmethionine (SAMe), a naturally occurring compound in the human body. Its primary functions include:
1. Liver Health:Promotes hepatocyte regeneration and detoxification. Used to treat liver disorders (e.g., cirrhosis, hepatitis, cholestasis) by enhancing glutathione synthesis and reducing oxidative stress.
2. Neurological and Psychiatric Applications: Modulates neurotransmitter synthesis (e.g., serotonin, dopamine), supporting the treatment of depression, anxiety, and cognitive disorders.
3. Joint Health: Stimulates proteoglycan synthesis in cartilage, aiding in osteoarthritis management.
4. Enhanced Stability: The 1,4-butanedisulfonate salt improves SAMe’s stability and bioavailability, ensuring longer shelf life and better therapeutic efficacy compared to free SAMe.
China holds significant competitive advantages in producing SAMe-1,4-butanedisulfonate:
1. Scalable Production: Large-scale fermentation and chemical synthesis facilities support high-volume output to meet global demand.
2. Advanced Technology: Adoption of cutting-edge biotechnological processes (e.g., microbial fermentation, enzymatic conversion) ensures high-purity SAMe synthesis.
3. Supply Chain Integration: Well-established raw material networks (e.g., methionine, ATP precursors) reduce lead times and production costs.
Customization Capabilities: Flexibility to produce tailored formulations (e.g., injectables, oral tablets) for diverse clinical needs.
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Pharma Sources Insight January 2025
