98.0% up by HPLC PDRN(PolyDeoxyRiboNucleotide) 100403-24-5/9007-49-2

PDRN is a DNA fragment extracted and purified from salmon sperm DNA through specific processes. It exhibits high biocompatibility and safety and is widely used in the field of regenerative medicine.

Core Mechanisms of Action

The primary effects of PDRN are regeneration and repair and anti-inflammation , mainly achieved through the following mechanisms:

1. Activation of Adenosine A2A Receptor:

This is the primary pathway through which PDRN acts. After entering the human body, PDRN is taken up by cells and degraded, producing a significant amount of adenosine. Adenosine binding to the A2A receptor on cell surfaces leads to:

• Significant promotion of tissue regeneration and repair : Stimulates the proliferation of fibroblasts, collagen, and vascular endothelial cells, accelerating the healing of soft tissues, bones, and cartilage.

• Powerful anti-inflammatory effects : Inhibits the release of multiple pro-inflammatory factors, reducing inflammatory responses and pain.

2. Providing Raw Materials for Nucleotide Synthesis :

As the basic structural unit of DNA/RNA, PDRN supplies essential "building blocks" for damaged or metabolically active cells (e.g., stem cells, immune cells), promoting cell proliferation and tissue regeneration.

3. Upregulation of Growth Factor Expression:

Studies show that PDRN can upregulate the expression of key growth factors (e.g., VEGF vascular endothelial growth factor, EGF epidermal growth factor), thereby promoting angiogenesis (supplying oxygen and nutrients to damaged tissues) and cell regeneration.

In summary, PDRN is a bioactive substance derived from natural salmon DNA. Through its dual mechanisms of activating repair signals (via A2A receptors) and supplying raw materials for repair nucleotides, it demonstrates remarkable effects in tissue regeneration, wound healing, and anti-inflammation across various fields. From widely known applications in aesthetic anti-aging to specialized treatments for refractory ulcers and orthopedic conditions, PDRN is becoming an increasingly important tool in regenerative medicine.