98% up Carbidopa Monohydrate 38821-49-7

Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:98% up Carbidopa Monohydrate 38821-49-7
CAS No.:38821-49-7
Standard:USP, BP, EP, JP, In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co.Ltd.

Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Xiamen, Fujian

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East

  • Monthly Production Capacity: 1000kg

    Packaging Information: 25kg/drum 1kg/bottle

  • Delivery Lead Time: 7 days after payment

    Sample Provided: yes

    Payment Terms: L/L

    Product Information

     

    Product name

    Carbidopa monohydrate

    Alias

    Benzenepropanoicacid, a-hydrazino-3,4-dihydroxy-a-methyl-, monohydrate, (S)-;Benzenepropanoic acid, a-hydrazino-3,4-dihydroxy-a-methyl-, monohydrate, (aS)- (9CI);

    CAS No.

    38821-49-7

    Molecular Formula

    C10H14N2O4*H2O

    Molecular Weight

    244.247

    Molecular Structure

    Quality Standard

    98% up by HPLC

    Appearance

    White to creamy white powder

     

    COA

     

    ANALYSIS

    SPECIFICATION

    RESULTS

    Appearance

    White to creamy white powder

    Conform

    Solubility

    Slightly soluble in water, freely soluble in 3 N hydrochloric acid, slightly soluble in methanol, practically insoluble in alcohol, in acetone, in chloroform, and in ether.

    Conform

    Identification

    IR: The spectrum of sample corresponds to that of the ref. standard.

    Conform

    HPLC: The retention time of sample of main peaks corresponds to that of the ref. standard.

    Complies

    Specific rotation

    -21° -23.5°

    -21.8°

    Loss on drying

    6.9%  7.9%

    7.2%

    Residue on ignition

     0.1%

    0.05%

    Heavy metals

     0.001%

    < 0.001%

    Methyldopa

    0.5%

    0.1%

    Carbidopa related compound A

    0.5%

    Negative

    Any other impurity

    0.1%

    0.01%

    Total impurities

    1.0%

    0.13%

    Residual solvents

    Should conform

    Conform

    Assay

    98.0% - 102.0%

    99.6%

    Conclusion

    The results above meet the requirements of USP39

     

    Usage

     

    What is Carbidopa?

    Parkinson’s disease is a degenerative condition that affects the central nervous system and causes difficulties controlling movements and impairs muscle function. It is thought to perhaps be the result of abnormally low levels of dopamine, a chemical in the brain that is responsible for a variety of functions, including controlling the body’s movement. The medication is typically only effective at treating Parkinson’s disease when it is combined with another drug known as levodopa. Carbidopa is a medication that is primarily used in treating the symptoms of Parkinson’s disease.

     

    Levodopa and carbidopa usually work together at treating the symptoms of Parkinson’s disease in a process. Since Parkinson’s disease is thought to be the result of low levels of dopamine, levodopa may help decrease Parkinson’s disease symptoms, such as tremors, stiffness, and muscle spasms, by increasing the amounts of dopamine in the body. When levopoda is taken, it turns into dopamine; however, the medication risks being metabolized by the body in the bloodstream before it can reach the brain as dopamine and effectively treat Parkinson’s disease symptoms. Carbidopa may help slow down the metabolizing of levopoda so that it has time to be released as dopamine in the brain, rather than being absorbed into the bloodstream.

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