99% up 5-Amino-3-(Trifluoromethyl) Picolinonitrile 573762-62-6

Name: 99% up 5-Amino-3-(Trifluoromethyl) Picolinonitrile 573762-62-6
Availability: 99-up-5-amino-3-trifluoromethyl-picolino-277114.html

Category:Intermediates > Pharmaceutical Intermediates
Product Name:99% up 5-Amino-3-(Trifluoromethyl) Picolinonitrile 573762-62-6
CAS No.:573762-62-6
Standard:USP, BP, EP, JP, In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co.Ltd.

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Product Information

Product name	5-Amino-3-(trifluoromethyl) picolinonitrile / Apalutamide intermediate
CAS No.	573762-62-6
Molecular Formula	C7H4 F3N3
Molecular Weight	187.124
Quality Standard	98% up by HPLC
Appearance	White powder

Molecular Structure:

Synonyms:	5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile; 5-Amino-2-cyano-3-(trifluoromethyl)pyridine; 5-Amino-3-(trifluoromethyl)2-cyanopyridine
EINECS:	815-137-9
Density:	1.45±0.1 g/cm3(Predicted)
Boiling Point:	362.2±42.0 °C(Predicted)
PSA:	62.70000
LogP:	2.13548

Usage

5-Amino-3-(trifluoromethyl) picolinonitrile is one of key intermediates of apalutamide (N-2).

Function of Apalutamide

As a second-generation nonsteroidal androgen receptor inhibitory drug, apalutamide can prevent the fusion of androgen and receptors, and block the transfer of AR to the nucleus of cancer cells. In addition, apalutamide can also control androgen and promote the growth of cancer cells.

The safety and efficacy of apalutamide are based on a randomized clinical trial of 1,207 patients with non-metastatic, castration-resistant prostate cancer. Patients in the trial received apalutamide or placebo. All patients also received hormone therapy, either with a gonadotropin-releasing hormone (GnRH) analog, or with surgery to lower the amount of testosterone in the body (surgical castration). Median metastasis-free survival was 40.5 months for patients taking apalutamide, compared with 16.2 months for patients taking placebo. From the above experiments, we can see that the effect of apalutamide in the treatment of prostate cancer is very significant.

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99% up 5-Amino-3-(Trifluoromethyl) Picolinonitrile 573762-62-6

Product Information

Product name

5-Amino-3-(trifluoromethyl) picolinonitrile /

Apalutamide intermediate

CAS No.

573762-62-6

Molecular Formula

C7H4 F3N3

Molecular Weight

187.124

Quality Standard

98% up by HPLC

Appearance

White powder

Molecular Structure:

Synonyms:

5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile; 5-Amino-2-cyano-3-(trifluoromethyl)pyridine; 5-Amino-3-(trifluoromethyl)2-cyanopyridine

EINECS:

815-137-9

Density:

1.45±0.1 g/cm3(Predicted)

Boiling Point:

362.2±42.0 °C(Predicted)

PSA:

62.70000

LogP:

2.13548

Usage

5-Amino-3-(trifluoromethyl) picolinonitrile is one of key intermediates of apalutamide (N-2).

Function of Apalutamide

As a second-generation nonsteroidal androgen receptor inhibitory drug, apalutamide can prevent the fusion of androgen and receptors, and block the transfer of AR to the nucleus of cancer cells. In addition, apalutamide can also control androgen and promote the growth of cancer cells.

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