99% up by HPLC Ademetionine 1,4-Butanedisulfonate SAM 101020-79-5

Name: 99% up by HPLC Ademetionine 1,4-Butanedisulfonate SAM 101020-79-5
Availability: 99-up-by-hplc-ademetionine-1-4-butanedis-273775.html

Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:99% up by HPLC Ademetionine 1,4-Butanedisulfonate SAM 101020-79-5
CAS No.:101020-79-5
Standard:USP, BP, EP, JP, In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co.Ltd.

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Product Information

Product name	Ademetionine 1,4-butanedisulfonate / SAM / SAMe
CAS No.	101020-79-5
Molecular Formula	C23H41N6O17S5-
Molecular Weight	833.91
Quality Standard	99% up by HPLC
Appearance	White powder

COA of Ademetionine 1,4-butanedisulfonate

ITEMS	STANDARDS	RESULTS
Appearance	A white or almost white powder	White powder
Solubility	Freely soluble in water, practically insoluble in ethanol and in acetone.	Conforms
Identification	1. The gas it produced can make wet potassium iodate test pater show blue.	Conforms
	2. UV: it has absorption maximum at the 258nm
	3. HPLC: the retention time of the principal peak in the chromatogram obtained with test solution is in accordance with that of the reference.
pH	2.1~2.5	2.4
Clarity and color of solution	Color: ≤Y3# or YG3#	Conforms
Clarity and color of solution	A solution should be clear.	Conforms
Isomers	(S,S-Isomer) ≥70%	74.00%
Related substances	Adenine≤0.4%	0.05%
	S-Adenosyl-L-Homocysteine≤0.4%	0.09%
	Methylthioadenosine≤2.0%	0.43%
	Decarboxylation adenosine methionine≤1.2%	1.00%
	The other unknown impurities≤1.0%	0.05%
	Total of impurities≤4.0%	1.80%
Water	≤6.0%	2.40%
Residual solvents	Ethyl acetate≤5000ppm	Conforms
Microbial limit tests	Bacteria≤1000cfu/g	Conforms
Bacterial endotoxins	≤0.438 EU/mg	Conforms
Content (dried basis)	Butanedisuphonic acid: 46.0~51.0%	47.20%
	Adenosine methionine: 48.0~53.0%	52.20%
	Total≥96.0%	99.40%
Conclusion	Conforms to enterprise standard

Usage

Function of Ademetionine 1,4-butanedisulfonate

Ademetionine 1,4-butanedisulfonate (SAM / SAMe) is a physiologically active molecule commonly found in human tissues and body fluids. It acts as a methyl donor (transmethylation) and a precursor of physiological sulfhydryl compounds (such as cysteine, taurine, glutathione, coenzyme A, etc.) (transsulfation) , participates important functions of biochemical reaction in the body.

The multiple mechanisms of adenosylmethionine are mainly reflected in the following aspects:

1. Transmethylation: Improve liver cell membrane fluidity, enhance Na+-K+-ATPase activity, promote bile secretion and operation, and participate in neurotransmitter synthesis, which can improve patient mood.

2. Transsulfide group: generate endogenous antidote, such as cysteine, glutathione, taurine, etc., play detoxification and antioxidant effects, and reduce liver cell damage.

3. Transformation of propylamino group: Synthesize biological polyamines, participate in metabolism in the body, regulate the regeneration and proliferation of liver cells, and accelerate the repair of liver function.

Indication of Ademetionine 1,4-butanedisulfonate:

Suitable for intrahepatic cholestasis before and after cirrhosis.

Suitable for intrahepatic cholestasis during pregnancy.

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99% up by HPLC Ademetionine 1,4-Butanedisulfonate SAM 101020-79-5

Product Information

Product name

Ademetionine 1,4-butanedisulfonate / SAM / SAMe

CAS No.

101020-79-5

Molecular Formula

C23H41N6O17S5-

Molecular Weight

833.91

Quality Standard

99% up by HPLC

Appearance

White powder

COA of Ademetionine 1,4-butanedisulfonate

ITEMS

STANDARDS

RESULTS

Appearance

A white or almost white powder

White powder

Solubility

Freely soluble in water, practically insoluble in ethanol and in acetone.

Conforms

Identification

1. The gas it produced can make wet potassium iodate test pater show blue.

Conforms

2. UV: it has absorption maximum at the 258nm

3. HPLC: the retention time of the principal peak in the chromatogram obtained with test solution is in accordance with that of the reference.

pH

2.1~2.5

2.4

Clarity and color of solution

Color: ≤Y3# or YG3#

Conforms

A solution should be clear.

Isomers

(S,S-Isomer) ≥70%

74.00%

Related substances

Adenine≤0.4%

0.05%

S-Adenosyl-L-Homocysteine≤0.4%

0.09%

Methylthioadenosine≤2.0%

0.43%

Decarboxylation adenosine methionine≤1.2%

1.00%

The other unknown impurities≤1.0%

0.05%

Total of impurities≤4.0%

1.80%

Water

≤6.0%

2.40%

Residual solvents

Ethyl acetate≤5000ppm

Conforms

Microbial limit tests

Bacteria≤1000cfu/g

Conforms

Bacterial endotoxins

≤0.438 EU/mg

Conforms

Content (dried basis)

Butanedisuphonic acid: 46.0~51.0%

47.20%

Adenosine methionine: 48.0~53.0%

52.20%

Total≥96.0%

99.40%

Conclusion

Conforms to enterprise standard

Usage

Function of Ademetionine 1,4-butanedisulfonate

The multiple mechanisms of adenosylmethionine are mainly reflected in the following aspects:

1. Transmethylation: Improve liver cell membrane fluidity, enhance Na+-K+-ATPase activity, promote bile secretion and operation, and participate in neurotransmitter synthesis, which can improve patient mood.

2. Transsulfide group: generate endogenous antidote, such as cysteine, glutathione, taurine, etc., play detoxification and antioxidant effects, and reduce liver cell damage.

3. Transformation of propylamino group: Synthesize biological polyamines, participate in metabolism in the body, regulate the regeneration and proliferation of liver cells, and accelerate the repair of liver function.

Indication of Ademetionine 1,4-butanedisulfonate: