Aminoglycosides are glycoside antibiotics formed by connecting amino sugars and amino cyclic alcohols through oxygen bridges. Aminoglycoside antibiotics are mainly used for systemic infections caused by sensitive aerobic Gram-negative bacilli. Aminoglycosides can inhibit protein synthesis. Aminoglycoside antibiotics display bactericidal activity against Gram-negative aerobes and some anaerobic bacilli where resistance has not yet arisen but generally not against Gram-positive and anaerobic Gram-negative bacteria.
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