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Clomiphene citrate is a kind of resistant hormone drug, also known as clodiphenolamine citrate, clotholamine, sullenol, clomiphene, with strong anti-estrogenic effect and weak estrogenic effect, easy to be absorbed in the gastrointestinal tract, and slowly excreted through the liver to the biliary tract, clinically suitable for the treatment of female infertility with a certain level of estrogen in the body, insufficient luteal function and male infertility with too little sperm, It is also used to test ovarian function and detect dysfunction of the hypothalamic (pituitary) gonadal axis in men. The mechanism of action works by competing binding to potent estrogen receptor sites within the hypothalamus. Estrogen is replaced from these sites, at which point the hypothalamus perceives a significant lack of circulating estrogen, resulting in gonadotropin-releasing hormone stimulating follicle-stimulating hormone (FSH) and luteinizing hormone (LH) secretion, which trigger a normal menstrual cycle.
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Pharma Sources Insight JANUARY 2024
